37115-38-1

Basic information

• Product Name: [8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl]-dimethyl-amine
• Synonyms: [8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl]-dimethyl-amine
• CAS NO: 37115-38-1
• Molecular Weight: 386.283
• Mol File: 37115-38-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl]-dimethyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl]-dimethyl-amine(37115-38-1)
• EPA Substance Registry System: [8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl]-dimethyl-amine(37115-38-1)

Safety Data

• Hazardous Substances Data: 37115-38-1(Hazardous Substances Data)

Upstream product

• 42292-42-2 8-chloro-6-(2-chlorophenyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 37115-32-5 adinazolam 
• 50-00-0 formaldehyd 
• 51511-12-7 8-chloro-1-(aminomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine 
• 40070-48-2 7-chloro-5-(o-chlorophenyl)-2-hydrazino-3H-1,4-benzodiazepine 
• 54304-87-9 8-chloro-6-(o-chlorophenyl)-1-(chloromethyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine 
• 124-40-3 dimethyl amine 

Downstream Products

• 58631-50-8 4-{2-[amino-(2-chloro-phenyl)-methyl]-4-chloro-phenyl}-3-(dimethylamino-methyl)-5-methyl-4H-[1,2,4]triazole 

Relevant articles and documents

1-(Aminoalkyl)-6-aryl;-4H-s-triazole[4,3-a][1,4]benzodiazepines with antianxiety and antidepressant activity

A series of 1-(Aminoalkyl)-6-aryl;-4H-s-triazole[4,3-a][1,4]benzodiazepines has been prepared and evaluated for central nervous system activity. The authors have found that members of this series have activity in pharmacological test systems designed to detect both anxiolytic and antidepressant activity. Each type of activity could be varied independently by appropriate substituent selections.

Intermediates and process for the production of certain triazolobenzodiazepines

A multi-step process for the preparation of 1-[(amino - or substituted amino)methyl]-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepines of the formula VI: SPC1 wherein R' is hydrogen or alkyl of 1 to 3 carbon atoms, inclusive, and wherein the rings A and B are unsubstituted or substituted by one or two substituents selected from the group consisting of chloro, fluoro, bromo, nitro, and trifluoromethyl, which comprises: treating a compound of the formula I: SPC2 wherein rings A and B are defined as above, with acetic anhydride and formic acid to obtain compound II: SPC3 wherein A and B rings have the significance as above, treating compound II with sufficient formaldehyde to produce compound III, the 3,5-bis(hydroxymethyl)derivative of II; treating III with phthalimide, triphenylphosphine and diethyl azodicarboxylate to give compound IV, the 3,5-bis(phthalimidomethyl) derivative of II; and treating IV with hydrazine hydrate to obtain a compound of formula V SPC4 wherein rings A and B are defined, as herein above. Compound V can then be alkylated in known manner to give those compounds of formula VIa which corresponds to formula VI when R' is desired to be alkyl. The compounds of formula VI have antidepressant and antianxiety effects in mammals and birds.