37122-50-2

Basic information

• Product Name: 2-(4-Methylphenyl)-1H-imidazole
• Synonyms: 2-(4-Methylphenyl)-1H-imidazole;2-(p-tolyl)-1H-imidazole
• CAS NO: 37122-50-2
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Mol File: 37122-50-2.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Methylphenyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methylphenyl)-1H-imidazole(37122-50-2)
• EPA Substance Registry System: 2-(4-Methylphenyl)-1H-imidazole(37122-50-2)

Safety Data

• Hazardous Substances Data: 37122-50-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 63, p. 2414, 2007 DOI: 10.1016/j.tet.2007.01.014

Upstream product

• 288-32-4 1H-imidazole 
• 106-49-0 p-toluidine 
• 104-87-0 4-methyl-benzaldehyde 
• 107-15-3 ethylenediamine 
• 131543-46-9 Glyoxal 
• 874-60-2 4-methyl-benzoyl chloride 
• 104-85-8 para-methylbenzonitrile 
• 13623-58-0 2-(p-tolyl)imidazoline 
• 108-88-3 toluene 
• 50846-98-5 2-Diazo-2H-imidazole 

Downstream Products

• 1253697-52-7 1-(phenylsulfonyl)-2-(p-tolyl)-1H-imidazole 
• 1400866-40-1 C₁₉H₁₉N₃O 
• 1400866-42-3 C₁₉H₁₈ClN₃O 
• 61698-35-9 2-p-tolyl-4,5-dihydroxymethyl imidazole 

Relevant articles and documents

A sustainable approach towards the three-component synthesis of unsubstituted 1H-imidazoles in the water at ambient conditions

A green protocol for the synthesis of unsubstituted imidazoles has been demonstrated herein. The reaction is realized using commercially available lipase enzyme, porcine pancreas lipase (PPL) in water. The reaction conditions are selective and mild which helped to tolerate a wide variety of functional groups to give the desired products in good chemical yields. (Figure presented.).

COMPOUNDS FOR TREATMENT OF CANCER

The present invention relates to pharmaceutical compositions for treating cancer comprising BRAF inhibitors, (e.g. vemurafenib) and/or MEK inhibitor, (e.g. trametinib, RO5068760), in combination with anti-tubulin compounds of the invention or other known tubulin inhibitors, and using such compositions for treating cancer such as melanoma, drug-resistant cancer, and cancer metastasis.

Synthesis, antimycobacterial activities and Docking studies of some novel diaryl imidazoles targeted at mycobacterium tuberculosis P-45014DM

A novel series of nine 2-(substituted phenyl)-1H-imidazol-1-yl-N- (substituted phenyl) alkanamides 3a-i were synthesized by reacting the corresponding w-chloroalkanamides 1 with 2-(substituted phenyl)-1H-imidazoles 2 in dimethylformamide. The compounds have been characterized on the basis of elemental analysis and spectral data. All the compounds were evaluated for their antimycobacterial activity. Among the synthesized compounds, N-(2,4-dinitrophenyl)-2-(2-(2-nitrophenyl)-1 H-imidazol-2-yl) propanamide 3e showed significant antimycobacterial activity when compared with the standard drug ethambutol. Docking studies with 14-a-demethylase (PDB ID IEA1) were also performed in order to investigate the binding pattern of these compounds.