371247-48-2

Upstream product

• 371247-47-1 (2S,1R)-2-(6-chloro(3-pyridyl))-4-oxocyclohexanecarboxamide 
• 75-65-0 tert-butyl alcohol 
• 371247-42-6 (4R)-3-{[(2S,1R,3R,4R)-6-aza-1-(triethylsilyloxy)-3-(6-chloro(3-pyridyl))-5-oxobicyclo[2.2.2]oct-2-yl]carbonyl}-4-benzyl-1,3-oxazolidin-2-one 
• 371247-44-8 (5S,1R,3R,4R)-3-aza-4-(triethylsilyloxy)-6-(6-chloro(3-pyridyl))-5-(methoxycarbonyl)bicyclo[2.2.2]oct-2-en-2-yl (tert-butoxy)formate 
• 371247-43-7 methyl (2S,1R,3R,4R)-6-aza-1-(triethylsilyloxy)-3-(6-chloro(3-pyridyl))-5-oxobicyclo[2.2.2]octane-2-carboxylate 
• 371247-45-9 methyl (6S,5R)-6-(6-chloro(3-pyridyl))-5-cyano-2-hydroxycyclohex-1-ene-carboxylate 
• 371247-46-0 (2S,1R)-2-(6-chloro(3-pyridyl))-4-oxocyclohexanecarbonitrile 
• 21543-49-7 2-Chloro-5-hydroxymethylpyridine 
• 23100-12-1 6-chloronicotinylaldehyde 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 371247-39-1 3-[(2E)-3-(6-chloro(3-pyridyl))prop-2-enoyl](4R)-4-benzyl-1,3-oxazolidin-2-one 

Downstream Products

• 211503-91-2 (-)-tert-butyl N-[(1R,2R,4S)-2-(6-chloropyridin-3-yl)-4-hydroxycyclohexyl]carbamate 
• 211503-92-3 N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide 
• 217323-82-5 (1R,2R,4R)-4-bromo-2-(6-chloropyridin-3-yl)cyclohexanamine 
• 140111-52-0 epibatidine 

Relevant academic research and scientific papers

Synthesis of (-)-epibatidine

matrix presented The synthesis of (-)-epibatidine has been accomplished utilizing a highly exo-selective asymmetric hetero Diels-Alder reaction. The key steps employed to transform the resulting bicycle into the natural product include a fluoride-promoted fragmentation and a Hofmann rearrangement.