37155-50-3

Basic information

• Product Name: 2-(4-Methoxybenzyl)phenol
• Synonyms: 2-(4-Methoxybenzyl)phenol;2-[(4-Methoxyphenyl)methyl]phenol
• CAS NO: 37155-50-3
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.2598
• Mol File: 37155-50-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 81-82 °C
• Boiling Point: 351 °C at 760 mmHg
• Flash Point: 187.7 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 2.09E-05mmHg at 25°C
• Refractive Index: 1.585
• PKA: 10.20±0.30(Predicted)
• CAS DataBase Reference: 2-(4-Methoxybenzyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxybenzyl)phenol(37155-50-3)
• EPA Substance Registry System: 2-(4-Methoxybenzyl)phenol(37155-50-3)

Safety Data

• Hazardous Substances Data: 37155-50-3(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxybenzyl)phenol, also known as 4-Methoxybenzylphenol, is a chemical compound with the molecular formula C14H14O2. It is a white to light yellow solid at room temperature and is commonly used in the production of fragrances and as a cosmetic preservative. 2-(4-Methoxybenzyl)phenol is a phenolic compound that is often utilized for its antimicrobial properties and is found in various personal care products such as lotions, shampoos, and soaps. Additionally, it has been studied for its potential antioxidant and anti-inflammatory properties, making it a versatile and valuable chemical in the cosmetic and pharmaceutical industries.

InChI:InChI=1/C14H14O2/c1-16-13-8-6-11(7-9-13)10-12-4-2-3-5-14(12)15/h2-9,15H,10H2,1H3

Upstream product

• 100-66-3 methoxybenzene 
• 18885-85-3 2-phenyl-4H-benzo-1,3,2-dioxaborine 
• 36192-61-7 2-amino-4'-methoxybenzophenone 
• 85604-67-7 2-(tetrahydropyran-2-yloxy)benzaldehyde 
• 90-02-8 salicylaldehyde 
• 108-94-1 cyclohexanone 
• 105-13-5 4-Methoxybenzyl alcohol 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 824-94-2 p-methoxybenzyl chloride 
• 108-95-2 phenol 
• 930-68-7 cyclohexenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 5449-69-4 2,4'-dimethoxybenzophenone 
• 30567-86-3 (2-methoxyphenyl)(4-methoxyphenyl)methanol 

Downstream Products

• 67346-47-8 2-(4-bromobutoxy)-4'-methoxydiphenylmethane 
• 1413373-38-2 C₄₉H₅₀O₇ 
• 1413373-40-6 C₄₉H₄₈O₇ 
• 1413373-42-8 C₄₉H₄₈F₂O₆ 
• 1413373-44-0 C₂₁H₂₄F₂O₆ 
• 1449602-81-6 C₂₁H₂₄O₆ 
• 1449602-82-7 C₃₃H₅₀O₁₀ 
• 1449602-84-9 C₃₃H₅₀O₁₀ 
• 1449602-85-0 C₂₁H₂₆O₆ 
• 1449602-87-2 C₂₁H₂₆O₆ 
• 1449602-83-8 C₂₁H₂₆O₆ 
• 875111-55-0 (1R,2S,3R,6R)-4-hydroxymethyl-6-[2-(4-methoxybenzyl)-phenoxy]cyclohex-4-ene-1,2,3-triol 
• 1449602-78-1 C₃₃H₄₈O₁₀ 
• 1449602-80-5 C₃₃H₄₈O₁₀ 

Relevant articles and documents

Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia

Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-molecule drugs capable of inducing it at the clinical level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and druggable angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and nondiabetic HLI mice. Together, this study offers a novel, promising small-molecule-based therapeutic strategy for treating HLI.

Catalytic Tandem and One-Pot Dehydrogenation-Alkylation and -Insertion Reactions of Saturated Hydrocarbons with Alcohols and Alkenes

The ruthenium-hydride catalyst has been successfully used for the tandem sp3 C-H dehydrogenation-alkylation reaction of saturated hydrocarbon substrates with alcohols to form the alkyl-substituted alkene and arene products. The analogous one-pot dehydrogenation-insertion of saturated ketones with alkenes and dienes directly yielded synthetically useful 2-alkylphenol and benzopyran products in a highly regio- and stereoselective manner without forming any wasteful byproducts. (Chemical Equation Presented).

Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors

Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent. Copyright