37172-84-2Relevant academic research and scientific papers
ACYLATION OF EXTENDED ENOLATE IONS FROM α-PHENYLTHIO(PhS-)CROTONATE ESTERS
Durman, John,Warren, Stuart
, p. 2895 - 2898 (1985)
C-Acylation, like alkylation, occurs at the α-position of title compounds to give unsaturated keto-esters from which the PhS group may be removed.
KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
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Page/Page column 90-91, (2011/10/31)
The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are a pharmaceutical composition and method of use thereof.
Privileged structure based ligands for melanocortin-4 receptors-Aliphatic piperazine derivatives
Briner, Karin,Collado, Iván,Fisher, Matthew J.,García-Paredes, Cristina,Husain, Saba,Kuklish, Steven L.,Mateo, Ana I.,O'Brien, Thomas P.,Ornstein, Paul L.,Zgombick, John,de Frutos, óscar
, p. 3449 - 3453 (2007/10/03)
Aliphatic carbocyclic replacement of the benzyl group of compound 1 yielded compounds with high affinity for the melanocortin-4 receptor (MC4R). Compounds with a cyclohexyl group showed a consistent high affinity, while different polar groups with less basicity were good replacements for the original diethyl amines. Substitution of the polar group found in these privileged structures with an aliphatic moiety produced compounds with high affinity for MC4R.
Synthesis of α-Phenylthio Enones and Esters of α-Phenylthio Alkenoic Acids
Durman, John,Grayson, J.Ian,Hunt, Paul G.,Warren, Stuart
, p. 1939 - 1946 (2007/10/02)
The title compounds can be made by a Pummerer dehydration from the corresponding saturated sulphoxides.The alkylation of anions from saturated and unsaturated ketones is described.
ALKYLATION OF EXTENDED ENOLATES FROM α-PHENYLTHIO CROTONATE ESTERS
Durman, John,Hunt, Paul G.,Warren, Stuart
, p. 2113 - 2116 (2007/10/02)
Conditions are described for the formation of enolate anions from substituted α-phenylthio-crotonate esters and their alkylation at the α-carbon atom.
