371775-73-4

Basic information

• Product Name: tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate
• Synonyms: tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate;(4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-[(Methylsulfonyl)aMino]-5-pyriMidinyl]ethenyl]-2,2-diMethyl-1,3-dioxane-4-acetic Acid 1,1-DiMethylethyl Ester
• CAS NO: 371775-73-4
• Molecular Formula: C28H38FN3O6S
• Molecular Weight: 563.6812232
• Product Categories: Aromatics Compounds;Aromatics;Bases & Related Reagents;Nucleotides;Sulfur & Selenium Compounds;Aromatics, Nucleotides, Bases & Related Reagents, Sulfur & Selenium Compounds
• Mol File: 371775-73-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 674.873°C at 760 mmHg
• Flash Point: 361.95°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate(371775-73-4)
• EPA Substance Registry System: tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate(371775-73-4)

Safety Data

• Hazardous Substances Data: 371775-73-4(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

InChI:InChI=1/C28H38FN3O6S/c1-17(2)24-22(25(18-9-11-19(29)12-10-18)31-26(30-24)32-39(8,34)35)14-13-20-15-21(37-28(6,7)36-20)16-23(33)38-27(3,4)5/h9-14,17,20-21H,15-16H2,1-8H3,(H,30,31,32)/b14-13+/t20-,21-/m1/s1

Upstream product

• 371775-72-3 C₂₇H₂₇FN₃O₃PS 
• 124752-23-4 tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate 
• 371775-70-1 C₁₆H₁₈FN₃O₄S 

Relevant articles and documents

Preparation method of demethylated rosuvastatin calcium

The invention discloses a preparation method of demethylated rosuvastatin calcium. A novel method for preparing the demethylated rosuvastatin calcium by taking a compound as shown in formula II as a raw material, introducing benzyl, then reducing and carrying out chlorination, removing the benzyl to generate triphenylphosphine salt, then carrying out reaction including condensation and the like isdeveloped through analyzing an electron cloud environment in a reactant molecule. According to the preparation method, the benzyl is introduced and a molecule electronic environment is changed; reduction reaction of a compound IV is carried out smoothly, a reduction product V is solidified and separation and purification of a later period are facilitated, so that the route has high reaction yieldand aftertreatment is simple and convenient; the preparation method is more suitable for batch production of the demethylated rosuvastatin calcium.