372107-34-1

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid, 3-(4-bromophenyl)-1-phenyl-
• CAS NO: 372107-34-1
• Molecular Formula: C16H11BrN2O2
• Molecular Weight: 343.18
• Mol File: 372107-34-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid, 3-(4-bromophenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid, 3-(4-bromophenyl)-1-phenyl-(372107-34-1)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid, 3-(4-bromophenyl)-1-phenyl-(372107-34-1)

Safety Data

• Hazardous Substances Data: 372107-34-1(Hazardous Substances Data)

Usage

Molecular Weight

344.18 g/mol

Structure

A pyrazole ring with a carboxylic acid group at position 4 and a 3-(4-bromophenyl)-1-phenyl substituent.

Class

Pyrazole derivatives

Applications

Potential applications in medicinal chemistry, pharmaceuticals, and agrochemicals development.

Biological Activities

Exhibits diverse biological activities.

Synthesis

Can be used as a building block for the synthesis of novel compounds with desired properties.

Research and Industrial Applications

Interesting target for further research and potential industrial applications due to its chemical structure and properties.

Upstream product

• 99-90-1 para-bromoacetophenone 
• 100-63-0 phenylhydrazine 
• 36640-41-2 3-(4-bromophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 

Downstream Products

• 373627-30-6 3-(4-bromo-phenyl)-1-phenyl-1H-pyrazole-4-carbonyl chloride 

Relevant articles and documents

Pyrazole-4-carboxylic Acids from Vanadium-catalyzed Chemical Transformation of Pyrazole-4-carbaldehydes

The conversion of aldehydes into carboxylic acids using oxidizing agents is a common protocol in transformation chemistry. An efficient oxidation strategy of transformation of pyrazole-4-aldehydes to the corresponding acids using vanadium catalysts in the presence of 30% H2O2 as an oxidant is described. The catalytic technology was successfully applied to a range of various 4-formylpyrazoles, and plausible mechanism is also discussed.

Synthesis of novel 6-(1H-pyrazol-4-yl)-[1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazoles as potential antimicrobial agents

Background: Triazolothiadiazoles are molecules of great synthetic and pharmacological significance. They are associated with significant antimicrobial, antifungal, antibacterial, antihelmintic and anti-inflammatory activities. Method: The condensation of 5-alkyl-4-amino-3-mercapto-4H-1, 2, 4-triazoles with 3-aryl-1- phenylpyrazole-4-carboxylic acids was carried out in the presence of phosphoryl chloride and the resulting products were tested in vitro for their antibacterial potential against Bacillus subtilis (gram positive), Staphylococcus aureus (gram positive), Escherichia coli (gram negative) and Pseudomonas aeruginosa (gram negative) and further antifungal properties against Candida albicans, and Saccharomyces cervisiae. Results: A new series of 3-alkyl-6-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-[1, 2, 4]triazolo[3, 4-b][1, 3, 4] thiadiazoles has been synthesized by the reaction mentioned above. One specific compound, 6-(3-(4- fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-methyl-[1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazole displayed an excellent antifungal activity against Candida albicans with a MIC value of 8 μg/ml, which is actually even better than the standard drug Amphoptericin B (MIC 10 μg/ml). Conclusion: An expeditious synthesis of several new 3-alkyl-6-(3-aryl-1-phenyl-1H-pyrazol-4-yl)- [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazoles in 77-89 % yield could be performed from readily accessible starting materials, 5-alkyl-4-amino-3-mercapto-4H-1, 2, 4-triazoles and 3-aryl-1-phenylpyrazole-4- carboxylic acids. Most of the resulting compounds showed moderate to good in vitro activity against Gram-positive bacteria. The title compounds seem to be more active against fungi than bacteria.