372160-55-9

Upstream product

• 98-61-3 p-Iodobenzenesulfonyl chloride 
• 6306-52-1 L-valine methylester hydrochloride 
• 4070-48-8 L-Valine methyl ester 
• 72-18-4 L-valine 

Downstream Products

• 685508-72-9 (S)-2-{4-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid methyl ester 
• 768388-38-1 2-(4'-benzyloxy-biphenyl-4-sulfonylamino)-3-methyl-butyric acid tert-butyl ester 
• 768388-35-8 (S)-2-(4'-Benzyloxy-biphenyl-4-sulfonylamino)-3-methyl-butyric acid methyl ester 
• 768388-36-9 (S)-2-(4'-Benzyloxy-biphenyl-4-sulfonylamino)-3-methyl-butyric acid 

Relevant academic research and scientific papers

Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents

Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2′,3′,4′-methoxybiphenyl-4-sulfonylamino)- butyric acid [11C]methyl ester (1a-c), (S)-3-methyl-2-(2′,3′,4′-fluorobiphenyl-4-sulfonylamino)- butyric acid [11C]methyl ester (1d-f), and (S)-3-methyl-2-(4′-nitrobiphenyl-4-sulfonylamino)-butyric acid [11C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents.

New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors

A series of derivatives of 2,4- and 2,5-thiazolyl- or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.