372948-82-8

Basic information

• Product Name: N-(6-FORMYLPYRIDIN-2-YL)PIVALAMIDE
• Synonyms: N-(6-FORMYLPYRIDIN-2-YL)PIVALAMIDE
• CAS NO: 372948-82-8
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.24
• Mol File: 372948-82-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(6-FORMYLPYRIDIN-2-YL)PIVALAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-FORMYLPYRIDIN-2-YL)PIVALAMIDE(372948-82-8)
• EPA Substance Registry System: N-(6-FORMYLPYRIDIN-2-YL)PIVALAMIDE(372948-82-8)

Safety Data

• Hazardous Substances Data: 372948-82-8(Hazardous Substances Data)

Usage

General Description

N-(6-Formylpyridin-2-yl)pivalamide is a chemical compound with the molecular formula C12H16N2O2. It is a pivalamide derivative with a formylpyridine group attached to the nitrogen atom. N-(6-FORMYLPYRIDIN-2-YL)PIVALAMIDE has potential applications in pharmaceutical and organic synthesis. It can be used as a building block or intermediate in the production of various organic compounds. Its structure and functional groups make it suitable for use in a range of chemical reactions and transformations. Further research and experimentation may reveal additional potential uses and properties of N-(6-Formylpyridin-2-yl)pivalamide.

Upstream product

• 111477-44-2 N-[6-(dibromomethyl)-2-pyridyl]pivalamide 
• 3282-30-2 pivaloyl chloride 
• 19798-81-3 2-Amino-6-bromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 221087-47-4 N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide 
• 86847-79-2 2,2-dimethyl-N-(6-methylpyridin-2-yl)propanamide 

Downstream Products

• 1404372-24-2 N,N′-(6,6′-(((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)-bis((pyridin-2-ylmethyl)azanediyl))bis(methylene))bis(pyridine-6,2-diyl))bis(2,2-dimethylpropanamide) 
• 1404372-25-3 2,6-bis((((6-aminopyridin-2-yl)methyl)(pyridin-2-ylmethyl)-amino)methyl)-4-methylphenol 
• 79651-64-2 (6-Amino-pyridin-2-yl)-methanol 
• 203321-88-4 (2R)-N-[1-(6-Aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide 

Relevant articles and documents

Self-assembled monolayer electrode of a diiron complex with a phenoxo-based dinucleating ligand: Observation of molecular oxygen adsorption/desorption in aqueous media

The phenoxo-based dinucleating ligand, 2,6-bis[bis(6-pivalamido-2- pyridylmethyl)amino-methyl]-4-aminophenol (1), and its Fe2(ii) complex, [Fe2(ii)(1)(PhCOO)2](CF3SO 3) (2), were prepared and 2 deposited on the Au surface (2/Au) is much more stable than in solution and exhibits redox behavior in aqueous media as well as reversible adsorption/desorption of oxygen at room temperature. The Royal Society of Chemistry.

Synthesis of a muscarinic receptor antagonist via a diastereoselective Michael reaction, selective deoxyfluorination and aromatic metal-halogen exchange reaction

An efficient synthesis of a structurally unique, novel M3 antagonist 1 is described. Compound 1 is conveniently disconnected retrosynthetically at the amide bond to reveal the acid portion 2 and the amine fragment 3. The synthesis of key intermediate 2 is highlighted by a ZnCl2-MAEP complex 19 catalyzed diastereoselective Michael reaction of dioxolane 7 with 2-cyclopenten-1-one (5) to establish the contiguous quaternary-tertiary chiral centers and a subsequent geminal difluorination of ketone 17 using Deoxofluor in the presence of catalytic BF3·OEt2. The synthesis of the amine moiety 3 is highlighted by the discovery of a novel n-Bu3MgLi magnesium-halogen exchange reaction for selective functionalization of 2,6-dibromopyridine. This new and practical metalation protocol obviated cryogenic conditions and upon quenching with DMF gave 6-bromo-2-formylpyridine (26) in excellent yield. Further transformations afforded the amine fragment 3 via reductive amination with 35, Pd-catalyzed aromatic amination, and deprotection. Finally, the highly convergent synthesis of 1 was accomplished by coupling of the two fragments. This synthesis has been used to prepare multi-kilogram quantities of the bulk drug.