221087-47-4

Usage

Uses

Given the limited information available on N-(6-Bromopyridin-2-YL)PIVALAMIDE, its uses can only be speculated based on its chemical structure and the properties of similar compounds. However, it is reasonable to assume that it may be employed in the following contexts:
Used in Pharmaceutical Research:
N-(6-Bromopyridin-2-YL)PIVALAMIDE could be used as a research compound for the development of new drugs, particularly in the field of medicinal chemistry. Its unique structure, including the bromine atom and the pivalamide group, may offer potential interactions with biological targets, making it a candidate for further investigation.
Used in Chemical Synthesis:
In the realm of organic chemistry, N-(6-Bromopyridin-2-YL)PIVALAMIDE might serve as an intermediate or a building block in the synthesis of more complex molecules. Its reactivity, due to the presence of the bromine atom and the amide functionality, could be exploited in various synthetic pathways.
Used in Material Science:
N-(6-BROMOPYRIDIN-2-YL)PIVALAMIDE may also find applications in material science, where its unique structural features could contribute to the development of new materials with specific properties. For instance, its potential use in the creation of novel polymers or as a component in advanced materials with tailored characteristics could be explored.

InChI:InChI=1/C10H13BrN2O/c1-10(2,3)9(14)13-8-6-4-5-7(11)12-8/h4-6H,1-3H3,(H,12,13,14)

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 754-10-9 2,2-dimethylpropionamide 
• 19798-81-3 2-Amino-6-bromopyridine 
• 3282-30-2 pivaloyl chloride 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 372948-82-8 2-pivaloylaminopyridine-6-carboxaldehyde 
• 851542-12-6 6-(diphenylphosphanyl)-N-pivaloyl-2-aminopyridine 
• 890049-05-5 C₂₄H₂₄N₂O 
• 852960-68-0 6-(1-naphthylphenylphosphino)-2-pivaloylaminopyridine 
• 1220596-31-5 benzyl 2-(6-pivalamidopyridin-2-yl)ethylcarbamate 
• 613678-03-8 (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone 
• 439239-90-4 Lasmiditan 
• 78177-12-5 6-(1-methylethyl)-2-pyridinamine 
• 1187541-07-6 2,2-dimethyl-N-{6-[1-({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)ethyl]pyridin-2-yl}propanamide 
• 1187541-00-9 6-[1-({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)ethyl]pyridin-2-amine 
• 857292-66-1 6-cyclopropyl-2-aminopyridine 
• 890049-06-6 C₁₈H₁₈N₂O 
• 681171-58-4 N-(6-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,5-dimethoxy-phenyl}-pyridin-2-yl)-2,2-dimethyl-propionamide 
• 681171-49-3 N-(6-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-ethyl-2-methoxy-phenyl}-pyridin-2-yl)-2,2-dimethyl-propionamide 

Relevant academic research and scientific papers

2,2-DIMETHYL-N-[6-(1-METHYL-PIPERIDIN-4-CARBONYL)-PYRIDIN-2-YL]-PROPIONAMIDE, METHOD FOR PREPARING (6-AMINO-PYRIDIN-2-YL)-(1-METHYL-PIPERIDIN-4-YL)-METHANONE USING SAID COMPOUND, AND USE OF SAID COMPOUND IN THE PREPARATION OF LASMIDITAN

The present invention relates to a new intermediate, (2,2-dimethyl-N-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-propanamide) useful in the synthesis of lasmiditan, to a method for obtaining same, to the use of said intermediate for preparing lasmiditan, to a method for preparing lasmiditan making use of said intermediate, and to a method for preparing an intermediate ((6-amino-pyridin-2-yl)-(1-methyl-piperidin-4-yl)-methanone) from (2,2-dimethyl-N-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-propanamide).

Synthesis method of 2-amino-6-(1-alkyl piperidine-4-carbonyl)pyridine compound

The invention relates to a synthesis method of a 2-amino-6-(1-alkyl piperidine-4-carbonyl)pyridine compound, and provides a method for synthesizing a 5-HT1f agonist pyridine carbonyl piperidine precursor (general formula 1), wherein an N-(6-bromopyridine-2-yl)amide compound (general formula 2) is converted into a corresponding metal reagent by using an organic metal reagent (RM), and is continuously subjected to an addition reaction with 1-alkyl piperidine-4-formamide or Weinreb's formamide thereof or formate (general formula 3), hydrolyzing is performed, and the protecting group of amide is removed to obtain the 2-amino-6-(1-alkyl piperidine-4-carbonyl) pyridine compound (general formula 1).

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PAIN

The invention relates to compounds, pyridine derivatives, and pharmaceutical 10 compositions containing same for use in the treatment of pain. It also relates to specific compounds, compositions comprising the same and uses thereof, in particular in the treatment of pain.

Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as the flexible linker

Forty-two compounds (series 8, 9 and 10) incorporated with diacylated piperazine have been synthesized and evaluated as novel Bcr-Abl inhibitors based on 'six-atom linker'. Five of them, 8d, 8h, 8l, 10m and 10p, displayed potent Bcr-Abl inhibitory activity comparable with Imatinib. Moreover, compounds 8e, 10q, 10s, and 10u were potent Bcr-Abl inhibitors with IC50 values at the sub-micromolecular level. Most compounds exhibited moderate to high antiproliferative activity against K562 cells. In particular, compound 9e was the most promising Bcr-Abl inhibitor. Docking studies revealed that the binding modes of these compounds were similar with Imatinib. These compounds could be considered as promising lead compounds for further optimization.

3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS

The present application relates to novel 3-(pyrazolyl)-lH-pyrrolo[2,3-b]pyridine derivatives of formula (I), as protein kinase inhibitors. The invention particularly relates to compounds of formula (I), preparation of compounds and pharmaceutical compositions thereof. The invention further relates to pharmaceutically acceptable salts and compositions comprising the said novel 3-(pyrazolyl)-lH-pyrrolo[2,3-b]pyridine derivatives and their use in the treatment of various disorders.

FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES

The present invention relates to hydroximoyl - tetrazole derivatives of formula (I), their process of preparation, preparation intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

NOVEL COMPOUNDS OF AMINO SULFONYL DERIVATIVES

The present invention relates to compounds with formula (I) or a pharmaceutically acceptable salt thereof: (I);wherein; T is a (4 to 10)-membered heterocyclyl and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of the 11-β-hsd-1 enzyme.

Self-assembly of bidentate ligands for combinatorial homogeneous catalysis based on an A-T base-pair model

The odd couple: Inspired by the principle of DNA base pairing a conceptually new approach for the generation of a heterobidentate-ligand library based on self-assembly through hydrogen-bonding is realized. From a 4 x 4 library a catalyst that shows outstanding activity and excellent regioselectivity could be identified (see scheme; FGR = functional group, Do = donor group). (Chemical Equation Presented)

Amino heterocyclyl inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

The present invention relates to compounds with the formula (I), or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) or formula (II) and methods of treating a condition that is mediated by the modulation of 11-β-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I) or formula (II).

Hydroformylation

The present invention relates to a process for hydroformylating in the presence of a catalyst comprising at least one complex of a metal of transition group VIII with mono-phosphorus compounds which are capable of dimerizing via noncovalent bonds as ligands, to such catalysts and to their use.