373-04-6Relevant articles and documents
Two-step preparation method of 6-aminocapronitrile
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Paragraph 0058-0059; 0061-0062; 0064-0065; 0067-0068; ..., (2021/08/28)
The invention relates to a two-step preparation method of 6-aminocapronitrile. The two-step preparation method comprises the following steps: carrying out ammonolysis reaction on caprolactam in an inert solvent or in a molten state and hot ammonia gas to obtain 6-aminohexanamide, and dehydrating the 6-aminohexanamide in the presence of a dehydrating agent to obtain 6-aminocapronitrile. According to the invention, ring-opening ammonolysis is carried out under an anhydrous condition, so that polymerization of ammonolysis products is effectively controlled, and generation of by-products is reduced; and under the condition of no catalyst, the dehydrating agent is directly used for dehydration reaction, so that the problems of catalyst coking, short catalyst service life and the like in a catalytic dehydration process are effectively avoided.
Process for the preparation of ε-caprolactam
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Page column 11,12, (2008/06/13)
Process for the preparation of ε-caprolactam, in which in a step (a) a compound with the general formula: O=CH—(CH2)4—C(O)—R??(1) in which R is —OH, —NH2or O—R′, in which R′ is an organic group with 1 to 10 carbon atoms, is contacted with ammonia and hydrogen in a suitable solvent at elevated pressure in the presence of a hydrogenation catalyst to a mixture of primary amino compounds and ε-caprolactam, followed by a separate second step (b) in which the primary amino compounds are reacted to ε-caprolactam, wherein the solvent in step (a) is an aqueous medium, including water, the yield to ε-caprolactam in step (a) is more than 10%, calculated on the initial molar amount of the compound according to formula (1), that ε-caprolactam is separated from the aqueous mixture obtained in step (a) by extraction and that the aqueous mixture resulting from the extraction, containing the primary amino compounds, is used in step (b).
Manufacture of 6-aminocaproamide
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, (2008/06/13)
A process for the manufacture of 6-aminocaproamide, wherein methyl or ethyl 5-cyanovalerate is reacted with excess ammonia at temperatures of from 25° to 200° C and the resulting 5-cyanovaleramide is hydrogenated at temperatures of from 25° to 200° C and pressures of from 50 to 300 bars in the presence of ammonia and of supported cobalt and/or nickel catalysts. 6-Aminocaproamide is suitable for the manufacture of caprolactam.