2432-74-8Relevant articles and documents
Freidlin,Sladkowa
, (1961)
Method for preparing 6-aminocapronitrile
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Paragraph 0053; 0057-0058; 0059; 0063-0064; 0065; 0069; ..., (2021/10/11)
The invention provides a method for preparing 6-aminocapronitrile, which comprises the following steps: (1) respectively preheating caprolactam and ammonia gas, and introducing the preheated caprolactam and ammonia gas into a micro-channel reactor I for reaction to obtain 6-aminohexanamide; (2) carrying out gas-liquid separation on a material obtained after the reaction in the step (1) to obtain a liquid-phase material 6-aminohexanamide; and (3) preheating the 6-aminohexanamide separated in the step (2), introducing the preheated 6-aminohexanamide into a micro-channel reactor II, and simultaneously introducing a dehydrating agent to carry out a dehydration reaction, thereby obtaining the 6-aminocapronitrile. According to the method, polymerization of ammonolysis products is effectively controlled, generation of by-products is reduced, a dehydrating agent is used for a dehydration reaction under the catalyst-free condition, and the problems of catalyst coking, short catalyst service life and the like in a catalytic dehydration process are effectively avoided.
Facile synthesis of supported Ru-Triphos catalysts for continuous flow application in selective nitrile reduction
Konrath, Robert,Heutz, Frank J.L.,Steinfeldt, Norbert,Rockstroh, Nils,Kamer, Paul C.J.
, p. 8195 - 8201 (2019/09/19)
The selective catalytic hydrogenation of nitriles represents an important but challenging transformation for many homogeneous and heterogeneous catalysts. Herein, we report the efficient and modular solid-phase synthesis of immobilized Triphos-type ligands in very high yields, involving only minimal work-up procedures. The corresponding supported ruthenium-Triphos catalysts are tested in the hydrogenation of various nitriles. Under mild conditions and without the requirement of additives, the tunable supported catalyst library provides selective access to both primary amines and secondary imines. Moreover, the first application of a Triphos-type catalyst in a continuous flow process is presented demonstrating high catalyst life-time over at least 195 hours without significant activity loss.