3734-22-3

Usage

InChI:InChI=1/C11H10O3/c12-10-7-14-11(13)9(10)6-8-4-2-1-3-5-8/h1-5,13H,6-7H2

Upstream product

• 4971-56-6 tetrahydrofuran-2,4-dione 
• 100-52-7 benzaldehyde 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 30030-96-7 3-(Phenylmethylene)-2,4(3H,5H)-furandione 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 81790-41-2 methyl-2-(chloroacetyl)-3-phenylpropanoate 
• 57956-49-7 {(1-methoxy-3-phenylprop-1-en-1-yl)oxy}trimethylsilane 

Downstream Products

• 1236161-65-1 (3S)-3-benzyl-3-(3-oxopentyl)furan-2,4(3H,5H)-dione 
• 1236161-76-4 (3aS,7aR)-(-)-7a-benzyl-3a-hydroxy-4-methyltetrahydro-2-benzofuran-1,5(3H,4H)-dione 
• 1236161-47-9 (3R)-(-)-3-benzyl-3-(3-oxobutyl)furan-2,4(3H,5H)-dione 
• 1236161-46-8 (3S)-(+)-3-benzyl-3-(3-oxobutyl)furan-2,4(3H,5H)-dione 
• 1236161-49-1 (3aR,7aS)-(+)-7a-benzyl-3a-hydroxytetrahydro-2-benzofuran-1,5(3H,4H)-dione 
• 1236161-50-4 (3aS,7aR)-(-)-7a-benzyl-3a-hydroxytetrahydro-2-benzofuran-1,5(3H,4H)-dione 
• 1338062-52-4 3-benzyl-3-[2,2-bis(4-chlorophenyl)ethenyl]tetrahydrofuran-2,4-dione 
• 1338062-45-5 3-[2-acetoxy-2,2-bis(4-chlorophenyl)ethyl]-3-benzyltetrahydrofuran-2,4-dione 

Relevant academic research and scientific papers

Synthesis of an Iridoid-Inspired Compound Collection and Discovery of Autophagy Inhibitors

Iridoids comprise a large group of monoterpenoid natural products displaying a diverse array of biological activities ranging from neurotrophic to anti-inflammatory and anti-tumorigenic properties. Therefore, the development of concise synthesis routes to compound collections inspired by the structural features of these natural products is of particular relevance for chemical biology and medicinal chemistry. Herein we describe a samarium diiodide-mediated synthesis of a small, focused iridoid-inspired compound collection. Characterization of these iridoid analogues in biological assays revealed novel small-molecule inhibitors of autophagy.

Synthesis of peroxylactones using Mn(III)-catalyzed aerobic oxidation

The aerobic oxidation of tetronic acid in the presence of 1,1-disubstituted alkenes afforded hydroperoxyethyl-peroxylactones, while a similar reaction using 3-alkyl-substituted tetronic acids gave stable crystalline peroxylactones in good to excellent yields. The oxidation using a stoichiometric amount of manganese(III) acetate did not give the bicyclic lactone but the ethenyland/ or ethyl-tetronic acid derivatives. The Japan Institute of Heterocyclic Chemistry.

Direct catalytic asymmetric synthesis of highly functionalized tetronic acids/tetrahydro-isobenzofuran-1,5-diones via combination of cascade three-component reductive alkylations and Michael-aldol reactions

A practical and sustainable chemical process for the synthesis of highly substituted tetrahydro-isobenzofuran-1,5-diones was achieved for the first time through asymmetric cascade Michael-aldol reaction of 4-hydroxy-3-alkyl-5H-furan- 2-ones with alkyl vinyl ketones in the presence of a catalytic amount of l-proline or 9-amino-9-deoxyepiquinine/TCA. In this article, we discovered for the first time the asymmetric synthesis of privileged bicyclic lactones through kinetic resolution and show the synthetic application to pharmaceuticals and natural products synthesis.

Cyclopentanone derivatives, method of synthesis and uses thereof

The present invention relates to cyclopentanone derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.