37389-79-0Relevant academic research and scientific papers
Quantitative structure-activity relationships of 2,4-diamino-5-(2-X- benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase
Selassie, Cynthia Dias,Gan, Wei-Xi,Kallander, Lara S.,Klein, Teri E.
, p. 4261 - 4272 (2007/10/03)
Quantitative structure-activity relationships (QSAR) have been formulated for a set of 15 2,4-diamino-5-(2-X-benzyl)pyrimidines versus dihydrofolate reductase from Lactobacillus casei and chicken liver. QSARs were also developed for comprehensive data sets containing mono-, di-, and trisubstituted benzyl derivatives. Particular emphasis was placed on the role played by ortho substituents in the overall binding process and subsequent inhibition of the catalytic process in both the prokaryotic and eucaryotic DHFRs. Comparisons between the two QSARs reveal subtle differences at specific positions which can be optimized to design more selective antibacterial agents.
Pharmaceutical compositions
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, (2008/06/13)
The compounds of the general Formula I STR1 (wherein R1 and R2 may be the same or different and each stands for hydrogen, hydroxy, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkoxy, C2-6 alkenyloxy or p
