37394-53-9

Upstream product

• 70-11-1 α-bromoacetophenone 
• 5520-62-7 1-(2-oxo-2-phenylethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.1(3,7)]decane bromide 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 101279-87-2 4-amino-3,5-diphenyl-2,3-dihydro-pyrrol-3-ol 
• 18807-52-8 N-Benzyloxycarbonyl-glycinphenacyl-amid 
• 102594-37-6 ω-<4-Styryl-benzoylamino>-acetophenon 
• 93961-59-2 2-(dimethylamino)-5-phenyl-1,3-oxazole 
• 714957-09-2 N-(2′-oxoethyl-2′-phenyl)-1-tosylpyrrole-2-carboxamide 
• 136802-80-7 2-Methylsulfanyl-1,5-diphenyl-1H-imidazole 
• 136802-82-9 1-p-Tolyl-5-phenyl-2-thiomethylimidazole 
• 136802-81-8 1-(4-Chloro-phenyl)-2-methylsulfanyl-5-phenyl-1H-imidazole 
• 136802-75-0 1-Ethyl-2-thiomethyl-5-phenylimidazole Hydroiodide 
• 136802-76-1 1-Etyhl-2-thiomethyl-3-methyl-5-phenylimidazole Iodide 
• 136802-83-0 1-p-Tolyl-2-thiomethyl-3-methyl-5-phenylimidazole Iodide 
• 136802-74-9 1-ethyl-2-thiomethyl-5-phenylimidazole 
• 68337-43-9 1-(4-methoxy-phenyl)-2-methylsulfanyl-5-phenyl-1H-imidazole 
• 5398-63-0 2,5-diphenylpyrazine 

Relevant academic research and scientific papers

Azole derivatives as histamine H3 receptor antagonists, Part 2: C-C and C-S coupled heterocycles

With a small series of compounds we demonstrated the variability in the core region of the human histamine H3 receptor (hH3R) antagonist structural blueprint by introducing polar azole groups (oxazole, oxadiazole, thiazole and triazole). Additional variations achieved by coupling different residues to the heterocyclic core structure led to further optimisation of in vitro receptor binding of the novel azole derivatives.

Investigations into the parallel synthesis of novel pyrrole-oxazole analogues of the insecticide pirate

Investigations into the parallel synthesis of selected analogues of a structurally unique pyrrole-oxazole analogue of the pyrrole insecticide pirate, are reported. Acylaminoketone salts were obtained from ketobromides in moderate to high yields and excell

Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate

The pyrrole oxazole 4 is a novel analogue of the broad-spectrum insecticide and miticide pirate 2. The expedient synthesis of pyrrole oxazole 4 in six steps from pyrrole is reported using a synthetic route that could have potential for the solution-phase

SYNTHESIS OF LUMINOPHORIC DERIVATIVES OF PBD BASED ON 2,5-DIARYL SUBSTITUTED THIAZOLES AND OXAZOLES

The Friedel-Crafts acylation of 2-(biphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole (PBD) with hippuryl chloride has been used to prepare the derivative V which on cyclization with POCl3 or P4S10 gives the respective oxazole (or thiazole) derivative of PBD, XIa or XIb.The reaction of carboxylic acid II with 4-(ω-aminoacetyl)biphenyl in the presence of CDI gives N-acyl-α-aminoketone VII; the analogous compound VI has been prepared by acylating ω-aminoacetophenone with acyl chloride III.The cyclization of these compounds gives bifluorophores Xa - Xd.