5520-62-7

Usage

Molecular Weight

314.4 g/mol

Structure

Contains a phenylethyl group and a triaza-azoniatricyclo[3.3.1.1~3,7~]decane ring system

Phenyl group

Aromatic ring with six carbon atoms and alternating single and double bonds

Ethyl group

A two-carbon alkyl chain

Oxo group

A carbonyl group (C=O)

Triaza

A nitrogen-containing ring with three nitrogen atoms

Azonia

Contains a positively charged nitrogen atom

Decane

A ten-carbon chain in the ring system

Medicinal Chemistry

As a building block for the synthesis of novel drugs

Pharmaceutical Research

As a molecular probe for studying biological processes

Materials Science

Due to its unique structure and properties

Organic Synthesis

As a component in the synthesis of other complex molecules

Biological Activity

May have potential biological activity, warranting further research

Research Importance

Further research on the properties and applications of 1-(2-oxo-2-phenylethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.1~3,7~]decane is needed due to its intricate structure and potential applications in various fields.

Upstream product

• 100-97-0 hexamethylenetetramine 
• 70-11-1 α-bromoacetophenone 
• 71-43-2 benzene 
• 98-86-2 acetophenone 

Downstream Products

• 68473-18-7 1-(4-methoxyphenyl)-5-phenyl-1H-imidazole-2-thiol 

Relevant academic research and scientific papers

Synthesis of a New Phorbazole and Its Derivatives

Phorbazoles are chlorinated marine alkaloids containing pyrrole, oxazole and phenol ring units, and differ in the number and positions of chlorine atoms. They are isolated from sea sponges and nudibranchs. In this work, a convenient synthetic method leading to a new phorbazole and its derivatives is developed. This synthesis of synthetic phorbazole G and its derivatives is achieved in seven steps in good overall yields of 26-52%. It involves formation of the pyrrole-oxazole skeleton followed by chlorination. The pyrrole-oxazole skeleton is synthesized from pyrrole and substituted acetophenones, and the key step involves cyclodehydration of amide intermediates to give protected oxazoles, followed by hydrolysis.

Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles

Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives have different pharmacological acti

Facile methods for the synthesis of 5-aryl and 5-iodo pyrrolo[2,3-d] pyrimidines

An efficient and environmentally benign one-pot method has been developed for the synthesis of 4-amino-5-arylpyrrolo[2,3-d]pyrimidines. Phthalimido acetophenones were reacted with cyanoacetamide to give 2-amino-4-phenyl-1H- pyrrole-3-carboxamides, which were further converted to 5-aryl-3H-pyrrolo[2,3-d] pyrimidin-4-ones. A novel method is also developed for the synthesis of 4-amino-5-iodopyrrolo[2,3-d]pyrimidines.

CHEMICAL COMPOUNDS

The invention is directed to 6-(4-pyι?midinyl)-1 H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1 - R4 are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Investigations into the parallel synthesis of novel pyrrole-oxazole analogues of the insecticide pirate

Investigations into the parallel synthesis of selected analogues of a structurally unique pyrrole-oxazole analogue of the pyrrole insecticide pirate, are reported. Acylaminoketone salts were obtained from ketobromides in moderate to high yields and excell

Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate

The pyrrole oxazole 4 is a novel analogue of the broad-spectrum insecticide and miticide pirate 2. The expedient synthesis of pyrrole oxazole 4 in six steps from pyrrole is reported using a synthetic route that could have potential for the solution-phase

SYNTHESIS OF LUMINOPHORIC DERIVATIVES OF PBD BASED ON 2,5-DIARYL SUBSTITUTED THIAZOLES AND OXAZOLES

The Friedel-Crafts acylation of 2-(biphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole (PBD) with hippuryl chloride has been used to prepare the derivative V which on cyclization with POCl3 or P4S10 gives the respective oxazole (or thiazole) derivative of PBD, XIa or XIb.The reaction of carboxylic acid II with 4-(ω-aminoacetyl)biphenyl in the presence of CDI gives N-acyl-α-aminoketone VII; the analogous compound VI has been prepared by acylating ω-aminoacetophenone with acyl chloride III.The cyclization of these compounds gives bifluorophores Xa - Xd.