374-14-1 Usage
Uses
Used in Pharmaceutical Industry:
2,2,3,3,3-PENTAFLUOROPROPYLAMINE HYDROCHLORIDE is used as a key intermediate for the synthesis of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein (CETP) inhibitors. These inhibitors play a crucial role in modulating lipid metabolism and have potential applications in the treatment of dyslipidemia and atherosclerosis.
In the synthesis process, 2,2,3,3,3-PENTAFLUOROPROPYLAMINE HYDROCHLORIDE serves as a building block to introduce the desired fluorinated propylamine moiety into the target molecule. This modification enhances the pharmacokinetic and pharmacodynamic properties of the final drug, making it more effective in addressing the underlying conditions.
Overall, 2,2,3,3,3-PENTAFLUOROPROPYLAMINE HYDROCHLORIDE is a valuable compound in the development of innovative therapeutic agents, particularly in the area of cardiovascular diseases. Its unique structural features and reactivity make it an essential component in the design and synthesis of novel CETP inhibitors and other related pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 374-14-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,7 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 374-14:
(5*3)+(4*7)+(3*4)+(2*1)+(1*4)=61
61 % 10 = 1
So 374-14-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H4F5N.ClH/c4-2(5,1-9)3(6,7)8;/h1,9H2;1H
374-14-1Relevant academic research and scientific papers
Soloshonok, Vadim A,Ohkura, Hironari,Uneyama, Kenji
, p. 5449 - 5452 (2002)
The first general method for the reducing reagent-free, biomimetic transformation of perfluorocarboxylic acids to the α,α-dihydroperfluoroalkyl amines is reported. High chemical yields and simplicity of the experimental procedure render this method immediately useful and synthetically superior to the conventional approaches relying on application of reducing reagents.
