37401-88-0

Upstream product

• 37166-60-2 (1E)-1-phenyl-5-(trimethylsilyl)pent-1-en-4-yn-3-one 
• 102-92-1 Cinnamoyl chloride 
• 1066-54-2 trimethylsilylacetylene 
• 14604-31-0 (E)-1-phenylpent-1-en-4-yn-3-ol 
• 31450-17-6 1-phenylpent-1-en-4-yn-3-ol 
• 155931-09-2 C₁₄H₁₈OSi 
• 104-55-2 3-phenyl-propenal 
• 501072-27-1 (E)-3-hydroxy-1-phenyl-5-trimethylsilyl-1-penten-4-yne 
• 80783-99-9 N-methoxy-N-methylcinnamamide 
• 4301-14-8 acetylenemagnesium bromide 

Downstream Products

• 37176-81-1 trans,trans-1,10-Diphenyldeca-1,9-dien-4,6-diin-3,8-dion 
• 37845-36-6 (E)-1,5-diphenyl-1-penten-4-yn-3-one 
• 42457-27-2 (E)-5-(2-phenylethyl)isoxazole 
• 153142-43-9 2-cinnamoylacetaldehyde-p-nitrophenylhydrazone 

Relevant academic research and scientific papers

A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.

Tertiary enamide-promoted diastereoselective domino: N-acyliminium ion trapping and nazarov cyclization

N-Acyliminium ions generated from enamidyl vinyl ketones provided cyclopentenoid-fused diazepines diastereoselectively using BF3·Et2O in one pot through a domino N-acyliminium ion trapping/Nazarov reaction, simultaneously generating three new stereogenic centers. The particular structural design of the cross-conjugated dienone dictates the torquoselectivity observed in this polarized Nazarov reaction. Various N-bridgehead polycyclic scaffolds of putative pharmacological interest were obtained. Cyclic voltammetry was used to support the preferred reaction sequence within this domino reaction.

Metal-free synthesis of activated ynesulfonamides and tertiary enesulfonamides

An operationally simple synthesis of activated ynesulfonamides and enesulfonamides is described. Ynesulfonamides can be obtained through reaction of sulfonylamides with activated bromoalkynes and Triton B in a short time at room temperature. Likewise, terminal alkynes react with sulfonylamides to provide enesulfonamides. Z/E enesulfonamides can be transformed exclusively into E enesulfonamides.

Styrene as 4π-Component in Zn(II)-Catalyzed Intermolecular Diels-Alder/Ene Tandem Reaction

A mild Zn-catalyzed intermolecular Diels-Alder/ene tandem reaction with styrene as a 4π-component is reported. A variety of dihydronaphthalene products could be prepared in moderate to good yields. Moreover, a combination of DFT calculations and experiments was performed to further understand the mechanism of this unique tandem reaction.

Vinyl Weinreb amides: A versatile alternative to vinyl ketone substrates for the Heck arylation

This paper describes the use of unsaturated Weinreb amides as excellent substrates for the Heck reaction. Subsequent derivatization of the products with organometallic reagents allowed access to a variety of substituted vinyl ketones that could not have been prepared directly via Heck reaction on unsaturated ketone precursors.

Calcium phosphate-vanadate apatite (CPVAP)-catalyzed aerobic oxidation of propargylic alcohols with molecular oxygen

Calcium phosphate-vanadate apatite (CPVAP) works effectively as a catalyst for the aerobic oxidation of propargylic alcohols to the corresponding carbonyl compounds under an atmospheric pressure of molecular oxygen. Moreover, CPVAP can be readily separated by filtration and reused at least 10 times without appreciable loss of the catalytic activity.

Oxovanadium complex-catalyzed aerobic oxidation of propargylic alcohols

A catalytic system consisting of vanadium oxyacetylacetonate [VO(acac)2] and 3 A molecular sieves (MS3A) in acetonitrile works effectively for the aerobic oxidation of propargylic alcohols [R1CH-(OH)C≡CR2] to the corresponding carbonyl compounds under an atmospheric pressure of molecular oxygen. Although the reactivity of α-acetylenic alkanols (R1 = alkyl) is lower compared to that of the alcohols of R1 = aryl, alkenyl, and alkynyl, the use of VO(hfac)2 as a catalyst and the addition of hexafluoroacetylacetone improve the product yield in these cases. A catalytic cycle involving a vanadium(V) alcoholate species and β-hydrogen elimination from it has been proposed for this oxidation.

Oxovanadium complex-catalyzed oxidation of propargylic alcohols using molecular oxygen

Oxovanadium complexes work as useful catalysts for the oxidation of propargylic alcohols to the corresponding carbonyl compounds in the presence of 3 ? molecular sieves under an atmospheric pressure of molecular oxygen.

Preparation of unsymmetrical dialkenyl ketones from the reactions of alkenyl alkynyl ketones with Gilman reagents

Unsymmetrical dialkenyl ketones were prepared from the reactions of alkenyl alkynyl ketones with 0.55 equiv of lithium dialkylcuprates.

The Synthesis of Electron Donor-acceptor Substituted Pyrazoles

A variety of 1,3- and 1,5-donor-acceptor substituted pyrazole derivatives have been synthesized by the cyclocondensation of α,β-ethynyl ketones with substituted phenyl hydrazines.The regioselectivity of the cyclization depends on the reaction conditions in a manner consistent with competitive 1,2- and 1,4-addition followed by ring closure. 1,4-disubstituted derivatives can be prepared from the corresponding 4-iodopyrazole using palladium catalyzed carbon-carbon bond forming reactions.The pyrazole chromophores are expected to show interesting nonlinear optical properties.