374073-47-9

Upstream product

• 267898-02-2 (E)-3-(But-2-enyloxy)-4-methoxybenzaldehyde 
• 188255-37-0 4-Methoxy-3-(1-methylprop-2-enyloxy)benzaldehyde 
• 621-59-0 isovanillin 
• 4784-77-4 (E)-1-Bromo-2-butene 

Downstream Products

• 374073-51-5 3-ethoxy-4-methoxy-2-(1-methylprop-2-enyl)benzaldehyde 
• 374073-52-6 3-(benzyloxy)-4-methoxy-2-(1-methylprop-2-enyl)benzaldehyde 
• 374073-50-4 3,4-dimethoxy-2-(1-methylprop-2-enyl)benzaldehyde 
• 1420805-24-8 3,4-dimethoxy-2-(3-oxobutan-2-yl)benzaldehyde 
• 1370593-45-5 [3,4-dimethoxy-2-(1-methyl-allyl)-phenyl]-(4-methoxy-phenyl)-methanone 
• 494798-17-3 1-allyloxymethyl-3-benzyloxy-4-methoxy-2-(1-methylallyl)benzene 
• 494798-10-6 3-benzyloxy-4-methoxy-2-(1-methylallyl)benzyl alcohol 
• 494798-16-2 1-allyloxymethyl-3-ethoxy-4-methoxy-2-(1-methylallyl)benzene 
• 494798-15-1 1-allyloxymethyl-3,4-dimethoxy-2-(1-methylallyl)benzene 
• 494798-09-3 3-ethoxy-4-methoxy-2-(1-methylallyl)benzyl alcohol 
• 494798-08-2 3,4-dimethoxy-2-(1-methylallyl)benzyl alcohol 
• 812646-78-9 3-(benzyloxy)-4-methoxy-2-(1-methyallyl)phenyl vinyl ketone 
• 778638-81-6 3-benzyloxy-4-methoxy-2-(1-methyl-2-propenyl)-1-vinylbenzene 
• 812646-77-8 3-ethoxy-4-methoxy-2-(1-methyallyl)phenyl vinyl ketone 

Relevant academic research and scientific papers

TBuO 2H/Cu(acac) 2-Mediated Intramolecular Oxidative Lactonization of o -Allyl Arylaldehydes: Synthesis of 1-Oxoisochromans

A concise route for the tBuO 2H/Cu(acac) 2-mediated synthesis of 1-oxoisochromans is described. This includes: (i) oxidation of oxygenated o -allyl arylaldehydes and (ii) sequential intramolecular lactonization of the resulting olefin-containing benzoic acids. A plausible mechanism is proposed and discussed.

Diethylaminosulfur Trifluoride (DAST)-Mediated Intramolecular Benzannulation of o-Allylchalcones: Synthesis of 3-Fluorotetralins

A concise route for the synthesis of 3-fluorotetralines is described, including: (i) NaBH 4 -mediated reduction of oxygenated o -allylchalcones and (ii) sequential DAST-mediated intramolecular annulation of the resulting alkenols. A plausible m

CuI Mediated One-Pot Cycloacetalization/Ketalization of o-Carbonyl Allylbenzenes: Synthesis of Benzobicyclo[3.2.1]octane Core

CuI/DMSO-mediated intramolecular cycloacetalization/ketalization of o-carbonyl allylbenzenes has been achieved for constructing [6,6,5]-tricycles having a ketal motif in good yields. The expeditious one-step route provides a three C-O bond formation. The key products with the structural framework of a benzofused dioxabicyclo[3.2.1]octane core have been confirmed by X-ray crystallographic analysis. Synthesis of dihydroisocoumarin has been studied.

Synthesis of polyoxygenated dibenzo[a,e]cycloheptatrienes

A successive route for the synthesis of substituted dibenzo[a,e]cycloheptatriene 1 was established by the reduction of 2-allylbenzaldehyde 4, the BF3·OEt2-mediated intermolecular coupling of 2-allylphenylmethanol 5 with oxygenated be

Synthesis of Substituted 2,3-Benzodiazepines

A new, four-step synthetic route for substituted 2,3-benzodiazepines 1, starting from aldehyde 4, was developed with excellent overall yields. This route included the 1,2-addition of various aromatic Grignard reagents to 4, PCC oxidation, and aerobic Wacker-type oxidation of the olefinic group of 6, followed by condensation of the resulting 1,5-dicarbonyl 7 with N2H4. Isoquinolones 9 were obtained when an aldehyde group was used instead of a ketone. The key structures were confirmed by X-ray single-crystal diffraction analysis.

Synthesis of substituted indenes from isovanillin via claisen rearrangement and ring-closing metathesis

A new synthesis of substituted indenes was studied. Based on Claisen rearrangement,Wittig reaction and ring-closing metathesis (RCM), a series of substituted indenes was synthesized from isovanillin in good yields.

One-pot access to 2-naphthols and benzofurans via the aerobic Wacker-type oxidation/intramolecular aldol cyclization

An aerobic Wacker-type oxidation/intramolecular aldol cyclization synthetic route toward two oxygenated 2-naphthols 3 and benzofurans 4 starting with skeleton 2 with good yields is described. The route has been carried by the one-pot transformation of the regioselective PdCl2/CuCl 2-mediated Wacker oxidative cyclization of skeleton 2 with molecular oxygen under the alkaline methanolic condition. Skeleton 2 was prepared from skeleton 1 in moderate total yields via the known protocol.

Synthesis of tetrahydroanthracen-9-ones by the domino aldol condensation/Diels-Alder cycloaddition

A facile protocol toward several substituted 3-aryl-3,4,4a,10-tetrahydro- 2H-anthracen-9-ones 1 starting with substituted 2-allylbenzaldehydes 2 was described. The overall synthetic process was carried out by the domino aldol condensation/Diels-Alder cycloaddition of skeleton 2 with substituted cinnamaldehydes 3 in an alkalic aqueous-methanolic solution followed by base-induced double migration of the resulting cycloadducts. Skeleton 2 was prepared from isovanillin (4) in moderate yield in five-steps via the known procedures with the synthetic sequence of O-allylation, Claisen rearrangement, O-methylation, Grignard methylation, and PCC-mediated oxidation.

Syntheses of substituted naphthalenes and naphthols

Syntheses of substituted naphthalenes and naphthols are described. Based on Claisen rearrangement, ring-closing metathesis (RCM), and related reactions, isovanillin was successfully transformed into a series of substituted naphthalenes and naphthols with

Synthesis of substituted indenes from isovanillin via claisen rearrangement and ring-closing metathesis

A new synthesis of substituted indenes was studied. Based on Claisen rearrangement, Wittig reaction and ring-closing metathesis (RCM), a series of substituted indenes was synthesized from isovanillin in good yields.