374077-87-9Relevant articles and documents
An alternative efficient approach for the synthesis of Fingolimod hydrochloride
Vinigari, Krishna,Jonnada, Krishna,Mohammed, Noorjahan,Kotu, Girija Mangatayaru
, p. 39 - 48 (2019/01/21)
An efficient process for the synthesis of API Fingolimod Hydrochloride is presented. This proposed synthesis involves simple commercially available octanophenone as a starting material. The route is effective involving seven steps to achieve the target, thus reducing the cycle time, and is cost efficient by 50%. It is an immune modulating drug for the treatment of heart failure and arrhythmias.
A hydrochloric acid profuse spear Pidotimod synthetic method and intermediate
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, (2017/04/27)
The invention provides a method and an intermediate for synthesizing Fingolimod hydrochloride. The method comprises the following steps: performing nitro-substitution, formaldehyde condensation, reduction and salification on octyl halogenated propylbenzene by using a novel intermediate, thereby obtaining the Fingolimod hydrochloride. The synthetic method is short in route, high in yield, low in cost, mild in reaction conditions, simple and convenient in operation and high in product purity and has high application value in large-scale industrial production.
PREPARATION OF FINGOLIMOD AND ITS SALTS
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, (2014/09/03)
The present application provide processes for the preparation of fingolimod and its pharmaceutically acceptable salts, process for the purification of fingolimod hydrochloride and process for the preparation of amorphous fingolimod hydrochloride.
METHODS AND COMPOUNDS FOR THE PREPARATION OF FLUORINE-LABELED DEOXY-FTY720
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Page/Page column 18-19, (2012/01/06)
Highly efficient processes for making radioactive and non-radioactive Fluorodeoxy- FTY720 are provided. Also provided are novel precursor compounds included in such processes. In addition the present invention prov ides compounds useful in the treatment a
Synthesis of 2-nitroalcohols by regioselective ring opening of epoxides with MgSO4/MeOH/NaNO2 system: A short synthesis of immunosuppressive agent FTY-720
Kalita,Barua,Bezbarua,Bez
, p. 1411 - 1414 (2007/10/03)
It has been demonstrated that a variety of epoxides can easily be opened with a system consisting of MgSO4/MeOH/NaNO2 giving the corresponding 2-nitroalcohols in excellent yields. This strategy has been applied to achieve a short synthesis of Immunosuppressive Agent FTY - 720.