57181-86-9

Usage

InChI:InChI=1/C15H17NO/c16-14-8-10-15(11-9-14)17-12-4-7-13-5-2-1-3-6-13/h1-3,5-6,8-11H,4,7,12,16H2

Upstream product

• 1693-39-6 N-(4-hydroxyphenyl)formamide 
• 637-59-2 1-Bromo-3-phenylpropane 
• 60091-85-2 1-nitro-4-(3-phenylpropoxy)benzene 
• 3742-75-4 3-phenylpropyl 4-methylbenzenesulfonate 
• 123-30-8 4-amino-phenol 
• 122-97-4 3-Phenyl-1-propanol 
• 103-90-2 4-acetaminophenol 
• 93406-75-8 N-(4-(3-phenylpropoxy)phenyl)acetamide 
• 100-02-7 4-nitro-phenol 
• 1124-31-8 potassium 4-nitrophenolate 

Downstream Products

• 57215-74-4 2-Chloro-3-[4-(3-phenyl-propoxy)-phenyl]-propionic acid ethyl ester 
• 60091-69-2 4-(3'-phenyl-propoxy)-phenyl-isothiocyanate 
• 35957-46-1 2-{[4-(3-Phenyl-propoxy)-phenylamino]-methylene}-malonic acid diethyl ester 
• 267416-52-4 3-Hydroxy-4-methoxy-4'-(3'-phenylpropyloxy)picolinanilide 

Relevant academic research and scientific papers

ICI 56,780 optimization: Structure-activity relationship studies of 7-(2-phenoxyethoxy)-4(1H)-quinolones with antimalarial activity

Though malaria mortality rates are down 48% globally since 2000, reported occurrences of resistance against current therapeutics threaten to reverse that progress. Recently, antimalarials that were once considered unsuitable therapeutic agents have been revisited to improve physicochemical properties and efficacy required for selection as a drug candidate. One such compound is 4(1H)-quinolone ICI 56,780, which is known to be a causal prophylactic that also displays blood schizonticidal activity against P. berghei. Rapid induction of parasite resistance, however, stalled its further development. We have completed a full structure-activity relationship study on 4(1H)-quinolones, focusing on the reduction of cross-resistance with atovaquone for activity against the clinical isolates W2 and TM90-C2B, as well as the improvement of microsomal stability. These studies revealed several frontrunner compounds with superb in vivo antimalarial activity. The best compounds were found to be curative with all mice surviving a Plasmodium berghei infection after 30 days.

Synthesis and biological evaluation of novel IM3829 (4-(2-cyclohexylethoxy)aniline) derivatives as potent radiosensitizers

Nuclear factor-erythroid 2-related factor 2 (Nrf2) regulates the expression of over 200 genes of antioxidant and phase II drug-metabolizing enzymes, and is highly expressed in non-small cell lung cancer (NSCLC). Nine derivatives of 4-(2-cyclohexylethoxy)aniline were designed. Our previous study demonstrated that IM3829 increases radiosensitivity of several lung cancer cells in vitro and in vivo. Here, biological effects of IM3829 derivatives (2a-2i) were evaluated. Compound 2g derivative effectively inhibits mRNA and protein expression of Nrf2 and HO-1. In addition, we observed over two fold enhancement in IR-induced cell death, from 2.90 ± 0.22 to 6.02 ± 0.87, in H1299 cancer cell-line. Among the nine derivatives, compound 2g derivative exhibited the highest enhancement of radiosensitizing effect via inhibition of Nrf2 activity.

2-Aminobenzothiazole derivatives: Search for new antifungal agents

A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized and screened in vitro as potential antimicrobials. Almost all the compounds showed antifungal activity. In particular, compounds 1n,o, designed on the basis of molecular modeling studies, were the best of the series, showing MIC values of 4-8 μg/mL against Candida albicans, Candida parapsilosis and Candida tropicalis. None of the two compounds did show any cytotoxicity effect on human THP-1 cells.

Stereoselective Synthesis and Binding Properties of Novel Concave-Shaped Indolizmo[3,4-b]quinolines

Novel all-cis-configurated indolizino[3,4-b]quinoline receptors 3,4 were prepared via diastereoselective Lewis acid-catalyzed cyclization of N-arylimines 6,7 as the key step. In order to obtain the indolizino[3,4-b]quinoline derivative 21 without a gem-di

Arylisothiocyanate for the regulation of plant growth

New arylisothiocyanates corresponding to the formula STR1 wherein R represents alkyl, alkoxy or halogen X represents oxygen or sulfur and P represents an integer of from 2 to 5 are disclosed. They can be used for the regulation of plant growth especially for the dessication and defoliation of unlignified parts of plants above the soil.