3743-23-5

Basic information

• Product Name: 5-chloro-2-methoxy-phenol
• Synonyms: 5-chloro-2-methoxy-phenol;4-Chloro-2-hydroxyanisole, 4-Chloro-2-hydroxyphenyl methyl ether;2-Hydroxy-4-chloroanisole;5-Chloroguaiacol;5-chloro-2-methoxyphenole
• CAS NO: 3743-23-5
• Molecular Formula: C₇H₇ClO₂
• Molecular Weight: 158.59
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 3743-23-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 161-163.5℃
• Boiling Point: 237-239℃ (760 Torr)
• Flash Point: 97.6°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 0.0286mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-chloro-2-methoxy-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-methoxy-phenol(3743-23-5)
• EPA Substance Registry System: 5-chloro-2-methoxy-phenol(3743-23-5)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 3743-23-5(Hazardous Substances Data)

Usage

General Description

5-Chloro-2-methoxyphenol is a chemical compound with the molecular formula C7H7O2Cl. It is an organic compound that contains a chlorine atom, a methoxy group, and a phenol group. 5-chloro-2-methoxy-phenol is commonly used in the production of dyes, pharmaceuticals, and pesticides. It is also known for its antifungal and antimicrobial properties, making it a valuable ingredient in a variety of personal care and cleaning products. 5-Chloro-2-methoxyphenol is typically a white to light yellow solid and is considered to be moderately toxic if ingested or absorbed through the skin. It is important to handle this chemical with care and in accordance with safety guidelines.

InChI:InChI=1/C7H7ClO2/c1-10-7-3-2-5(8)4-6(7)9/h2-4,9H,1H3

Upstream product

• 56-23-5 tetrachloromethane 
• 507-40-4 tert-butylhypochlorite 
• 90-05-1 2-methoxy-phenol 
• 89694-48-4 5-chloro-2-methoxyphenyl boronic acid 
• 58735-58-3 2-(bromomethyl)-4-chloro-1-methoxybenzene 
• 7035-09-8 5-chloro-2-methoxybenzaldehyde 
• 95-03-4 5-chloro-2-methoxyaniline 
• 636-93-1 5-nitroguaiacol 
• 623-12-1 4-chloromethoxybenzene 

Downstream Products

• 256431-59-1 1-methoxy-2-methoxymethoxy-4-chlorobenzene 
• 895572-26-6 3-chloro-5-(4-chloro-2-hydroxyphenoxy)benzonitrile 
• 1351861-67-0 3-chloro-2-(5-chloro-2-methoxyphenoxy)benzonitrile 
• 1351862-45-7 3-chloro-5-(5-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)benzonitrile 
• 1351862-44-6 3-chloro-2-(5-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)benzonitrile 
• 1351862-43-5 5-(5-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)isophthalonitrile 
• 1351861-78-3 3-(2-(2-bromoethoxy)-5-chlorophenoxy)-5-chlorobenzonitrile 

Relevant articles and documents

COMPOUNDS FOR USE AS RADIOLIGANDS

The present invention relates to compounds, in particular those of formula (I) and formula (II) described herein, or pharmaceutically acceptable salts or solvates thereof, which may be used as radioligands in in vitro, ex vivo and in vivo beta cell imagin

Combined Directed ortho Metalation/Suzuki-Miyaura cross-coupling strategies. Regiospecific synthesis of chlorodihydroxybiphenyls and polychlorinated biphenyls

(Chemical Equation Presented) The Directed ortho Metalation (DoM)/Suzuki-Miyaura cross-coupling strategy is applied for the regiospecific construction of all isomeric monochloro and selected dichloro and trichloro 2,3-dihydroxybiphenyls (DHBs). The combined methodology highlights iterative DoM processes, hindered Suzuki-Miyaura couplings, and advantages in diversity in approaches from commercial starting materials leading to provision of chloro-DHBs as single isomers in high purity and on a gram scale. The syntheis of several PCBs are also reported.

Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine D4 receptor antagonists

The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R12, R13, R14and R15each independently are hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, nitro, cyano, amino, acyl, alkylamino, dialkylamino, aminocarbonyl, or acylamino; R5 is hydrogen, alkyl, alkoxyalkyl, or phenylalkyl; X is —CH2—Z—, Z—CH2—, NH—CO—, —CO—NH—, or —CH═CH—; wherein Z is O, S, CH2, or NH; Y is O, —CH2—W—, —W—CH2—; wherein W is O, or S; and n is 0, 1 or 2. The compounds are useful in the treatment of psychotic disorders.