66037-03-4

Usage

Class

Acetophenones

Solubility

Soluble in organic solvents

Applications

Intermediate in pharmaceutical synthesis
Intermediate in agrochemical synthesis
Intermediate in organic compound synthesis

Potential Applications

Preparation of fine chemicals
Production of pharmaceutical products

Handling and Storage

Requires careful handling and storage to prevent harmful exposure

Upstream product

• 613-70-7 2-methoxyphenyl acetate 
• 623-12-1 4-chloromethoxybenzene 
• 64-19-7 acetic acid 
• 3743-23-5 5-chloro-2-methoxyphenol 
• 108-24-7 acetic anhydride 

Downstream Products

• 69240-98-8 6-chloroacetoguaiacone 
• 85430-09-7 4-chloroguaiacol acetate 
• 501-19-9 chavibetol 

Relevant academic research and scientific papers

Direct Acetoxylation of Arenes

Acetoxylation of arenes is an important reaction and an unmet need in chemistry. We report a metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid, and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism is proposed.

Expeditious synthesis of bioactive allylphenol constituents of the genus Piper through a metal-free photoallylation procedure

Nine bioactive allylphenol (anisole) derivatives (e.g. eugenol, safrole and asaricin) present in several plants of the genus Piper have been synthesized in medium to high yield via aryl cation intermediates. This expeditious metal-free procedure involves the irradiation of the corresponding chlorophenols or chloroanisoles in a polar solvent (MeCN or, better, TFE or aqueous acetonitrile) in the presence of allyltrimethylsilane. Estragole has also been synthesized starting from the corresponding fluoroderivative and diazonium salt, though in a lower yield. The Royal Society of Chemistry 2005.