37441-51-3

Upstream product

• 37441-50-2 1,4-butanesultam 
• 108-88-3 toluene 
• 100-46-9 benzylamine 
• 500123-71-7 4-benzylamino-butane-1-sulfonic acid 
• 1633-83-6 1,4-butane sultone 

Downstream Products

• 905975-55-5 ((S)-1-{(S)-1-Benzyl-2-[2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-(6E)-ylidene]-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid tert-butyl ester 
• 905975-56-6 ((S)-1-{(S)-1-Benzyl-2-[2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-(6Z)-ylidene]-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid tert-butyl ester 
• 905975-61-3 (S)-2-Amino-4-methyl-pentanoic acid {(S)-1-benzyl-2-[2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-(6E)-ylidene]-ethyl}-amide 
• 905975-62-4 (S)-2-Amino-4-methyl-pentanoic acid {(S)-1-benzyl-2-[2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-(6Z)-ylidene]-ethyl}-amide 
• 905975-37-3 [1-benzyl-2-(2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-6-ylidene)-ethyl]-carbamic acid tert-butyl ester 
• 905975-41-9 [1-benzyl-2-(2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-6-ylidene)-ethyl]-carbamic acid tert-butyl ester 
• 905975-45-3 (S)-1-Benzyl-2-[2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-(6E)-ylidene]-ethylamine 
• 905975-49-7 (S)-1-Benzyl-2-[2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-(6Z)-ylidene]-ethylamine 
• 905975-33-9 (2-benzyl-1,1-dioxo-1λ⁶-[1,2]thiazinan-6-yl)-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Copper-catalyzed amination of primary benzylic C?H bonds with primary and secondary sulfonamides

A room-temperature, copper-catalyzed amination of primary benzylic C?H bonds with primary and secondary sulfonamides is described. The reaction is applicable to the coupling of a range of primary and secondary benzylic hydrocarbons with a diverse set of sulfonamides and is tolerant of substitution on both coupling partners. Factors which influence the selectivity of C?H functionalization between primary and secondary sites are examined.

Dipeptide vinyl sultams: Synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

The synthesis of phosphonate derivatives of N-phenyl- and N-benzyl-γ- and δ-sultams, and their application in the Wittig-Horner reaction with N-Boc-l-phenylalanine aldehyde to afford E- and Z-isomers, are described. These compounds were further processed to provide five dipeptide vinyl sultams, which were found to be inactive against papain at concentrations up to 50 μM. In contrast, vinyl sultams demonstrated weak activity against recombinant falcipain-2 and Plasmodium falciparum W2.