37459-57-7

Upstream product

• 51334-76-0 4-(4-methylphenyl)-2,3-benzoxazin-1-one 
• 30696-82-3 3-Chlor-isoindolin-1-on 
• 108-88-3 toluene 
• 136918-14-4 phthalimide 
• 26486-93-1 3-hydroxy-2,3-dihydro-isoindol-1-one 
• 7468-67-9 o-formylbenzonitrile 
• 5398-16-3 2-(4-methyl-benzyl)-benzoic acid 
• 39127-18-9 3-hydroxy-3-(4-methylphenyl)-2,3-dihydro-1H-isoindol-1-one 
• 4294-57-9 para-methylphenylmagnesium bromide 

Downstream Products

• 25365-85-9 3-Methoxy-1-(4-methylphenyl)-1H-isoindol 
• 83889-40-1 3-Methoxy-1-(4-methylphenyl)-1H-isoindolium-trifluoromethansulfonat 

Relevant academic research and scientific papers

Compound with BRD4 inhibitory activity, preparation method and application thereof

The invention discloses a compound with BRD4 inhibitory activity, a preparation method and application thereof. The structure of the compound with the BRD4 inhibitory activity is shown as a formula I, and definitions of substituent groups are shown in the specification and claims. The compound provided by the invention has very high bromodomain protein inhibition activity, especially BRD4 targeted inhibition activity, and can be used for treating or/and preventing related diseases mediated by bromodomain protein.

Isoindolinones via Copper-Catalyzed Intramolecular Benzylic C-H Sulfamidation

2-Benzyl-N-tosylbenzamides and related substrates undergo copper-catalyzed intramolecular sulfamidation at the benzylic methylene to give N-arylsuflonyl-1-arylisoindolinones, which can be N-deprotected using samarium iodide to generate the free 1-arylisoindolinones. Preliminary mechanistic studies indicate that the rate-determining step is not C-H bond cleavage but are instead consistent with slow oxidation of a copper π-arene intermediate.

TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction

A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C-H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.

Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXVIII. 3-Alkoxy-1H-isoindole mit Substituenten am 5-Ring - Heterocycliche Imidsaeureester mit fixierter benzoider Struktur.

3-Alkoxy-1H-isoindoles bearing substituents at the five-membered ring have been synthesized starting with substituted isoindoline-1-ones via regiospecific O-alkylation with trialkyl oxonium tetrafluoroborates or alkyl trifluoromethanesulfonates and subsequent NH-deprotonation.The dependence of spectroscopic properties on the substituents has been investigated.The heterocyclic imidates exist exclusively in the benzenoid 1H-structure; the tautomeric o-quinonoid 2H-form cannot be detected by spectroscopic means.