374674-79-0Relevant academic research and scientific papers
Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus
Donkor,Sanders, M. Lee
, p. 2647 - 2649 (2001)
The reported diketopiperazine calpain inhibitor, cis-L-L-3,6-bis-(4-hydroxybenzyl)-1,4-dimethylpiperazine-2,5-dione 1, and its analogues 3 and 4 were synthesized from the corresponding amino acids. The previously assigned structure of 1 is confirmed but n
Conformations of Six N-Methylated Diketopiperazines in Solution
Radding, W.,Donzel, B.,Ueyama, N.,Goodman, M.
, p. 5999 - 6005 (1980)
The conformations of six N-methylated diketopiperazines in solution are determined by a combination of NMR and CD techniques and compared to results of X-ray crystallography.Of the six compounds, three apparently have conformations in solution substantial
ASSYMETRIC SYNTHESIS OF A PIPERAZINE ALKALOID
Takeuchi, Seiji,Ohgo, Yoshiaki,Miyoshi, Norikazu,Shin, Chun-gi,Yonezawa, Yasuchika
, p. 2073 - 2078 (2007/10/02)
A piperazine alkaloid, (2S,5S)-2,5-dibenzyl-1,4-dimethylpiperazine, was synthesized by reduction of (3S,6S)-3,6-dibenzyl-1,4-dimethyl-2,5-piperazinedione which was prepared by a catalytic asymmetric hydrogenation of the corresponding 3,6-dibenzylidene der
Pyrazine Chemistry. III. Synthesis and Stereochemistry of 1,4-Dimethyl and 1,4-Diacetyl Derivatives of 3,6-Dibenzylpiperazine-2,5-dione
Marcuccio, Sebastian M.,Elix, John A.
, p. 2397 - 2402 (2007/10/02)
The trans- and (+/-)cis-isomers of 1,4-dimethyl-and 1,4-diacetyl-3,6-dibenzylpiperazine-2,5-dione were synthesized.The hydriodic acid reduction of 3,6-dibenzylidene-1,4-dimethylpiperazine-2,5-dione gave (+/-)-cis-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione although this product has previously been assigned the trans-geometry.The unknown isolated from the permanganate oxidation of (+)-cis-1,4-diacetyl-3,6-dibenzylpiperazine-2,5-dione has been identified as the corresponding trans-isomer.
