374803-72-2

Upstream product

• 60080-98-0 (2-bromo-5-methoxyphenyl)(phenyl)methanone 
• 1184937-09-4 4-bromo-3-(hydroxy(phenyl)methyl)phenol 
• 374803-67-5 2-bromo-N,5-dimethoxy-N-methylbenzamide 
• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 

Downstream Products

• 1184937-06-1 C₁₄H₈BrClO₃ 
• 374803-70-0 (2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}propanoic acid 
• 374803-68-6 (2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester 
• 374803-66-4 (S)-2-[2-Benzoyl-4-(2-trimethylsilanyl-ethoxymethoxy)-phenylamino]-3-(4-benzyloxy-phenyl)-propionic acid 
• 374803-65-3 {2-bromo-5-[2-(trimethylsilyl)ethoxymethoxy]phenyl}(phenyl)methanone 

Relevant academic research and scientific papers

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates - subtype selective, high affinity α7 nicotinic acetylcholine receptor agonists

The synthesis and SAR studies about the bicyclic amine, carbamate linker and aromatic ring of a 1,4-diazabicyclo[3.2.2]nonane phenyl carbamate series of α7 nAChR agonists is described. The development of the medicinal chemistry strategy and SAR which led to the identification of 5 and 7aa as subtype selective, high affinity α7 agonists as excellent leads for further evaluation is discussed, along with key physicochemical and pharmacokinetic data highlighting their lead potential.

The synthesis of GW710936X to support the development of potent PPARγ agonists

(2S)-[(2-Benzoyl-4-hydroxy-phenyl)amino]-3-{4-[2-(5-methyl-2-phenyloxazol-4- yl)ethoxy]phenyl}propanoic acid has been synthesised from N-Cbz-L-tyrosine methyl ester utilising a copper(I) catalysed N-arylation as the key coupling step. The synthetic route