37503-18-7

Upstream product

• 64-19-7 acetic acid 
• 1027915-84-9 3-Ethyl-5-phenyl-4,5-dihydro-isoxazol-5-ol 
• 100-39-0 benzyl bromide 
• 95-45-4 butane-2,3-dione dioxime 
• 93-58-3 benzoic acid methyl ester 
• 79014-36-1 (E/Z)-N-Isopropyl(1-methylpropyliden)amin 
• 1721-84-2 4-phenyl-3-methyl-3-butene-2-one oxime 
• 1008-75-9 3-methyl-5-phenylisoxazole 
• 74-88-4 methyl iodide 
• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 71-43-2 benzene 
• 110-46-3 isopentyl nitrite 

Downstream Products

• 80949-36-6 4-Chloro-3,4-dimethyl-5-phenyl-4,5-dihydro-isoxazol-5-ol 

Relevant academic research and scientific papers

Contrasting C- and O-Atom Reactivities of Neutral Ketone and Enolate Forms of 3-Sulfonyloxyimino-2-methyl-1-phenyl-1-butanones

The mechanisms of intramolecular cyclization of 3-sulfonyloxyimino-2-methyl-1-phenyl-1-butanones (1) under basic (DABCO and t-BuOK) and acidic (AcOH and TFA) conditions were investigated by means of experimental and computational methods. The ketone, enol

An efficient, scaleable procedure for the conversion of esters to isoxazoles

A concise, regiocontrolled route to isoxazoles, based on the condensation of an ester with a metallated imine, has been developed. The intermediate vinylogous amides react smoothly with hydroxylamine to provide, after dehydration, substituted isoxazoles. The method has been used for the multi-kilo scale preparation of ABT-418, a novel cholinergic channel activator.

The thermolysis of benzyl cobaloximes: A new one step synthesis of 5-arylisoxazoles

When benzyl cobaloximes are either dry-distilled or boiled in xylene solution they afford the corresponding 5-arylisoxazoles in moderate to good yields.

The Reaction of Carbanions from 3-Methyl-5-phenylisoxazole with Electrophilic Compounds

The reactivity of 3-methyl-5-phenylisoxazole against electrophilic compounds in the presence of different bases is studied.With n-BuLi, alkylated products at C-4 position and C-3 methyl group, and, in a few cases, dialkylated isoxazoles are obtained.When

Halogenation of Vinyl Ketoximes. Synthesis of Isoxazoles and Preparation and Silver Ion-Promoted Reactions of 4-Halo-2-isoxazolines

Reaction of several α,β-unsaturated ketoximes with N-bromosuccinimide (NBS) gave isoxazoles, but yields were lower and the reaction less general than a similar transformation using iodine under basic conditions.With β,β-disubstituted oximes, 4-halo-5,5-disubstituted-2-isoxazolines were obtained using NBS, iodine, or N-chlorosuccinimide.Treatment of the 4-bromoisoxazolines with silver acetate or silver nitrate caused either elimination with rearrangement to give isoxazoles or substitution at C-4, depending upon the nature of the substituents at C-5.