37527-68-7

Usage

Uses

Used in Pharmaceutical Industry:
(2-amino-4-methoxyphenyl)(phenyl)methanone is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with potential therapeutic benefits.
Used in Fragrance Industry:
As an intermediate, (2-amino-4-methoxyphenyl)(phenyl)methanone is used in the creation of fragrances, taking advantage of its reactive functional groups to produce a wide range of scent compounds that can be used in perfumes, cosmetics, and other scented products.
Used in Organic Synthesis:
(2-amino-4-methoxyphenyl)(phenyl)methanone is utilized as a building block in organic synthesis, allowing chemists to construct a variety of organic compounds for research and commercial applications, such as dyes, agrochemicals, and other specialty chemicals.
Used in Biological Research:
(2-amino-4-methoxyphenyl)(phenyl)methanone is employed in biological research as a subject of study for its potential anti-cancer and anti-inflammatory properties, with the aim of discovering new therapeutic agents and understanding their mechanisms of action.
Used in Drug Development:
(2-amino-4-methoxyphenyl)(phenyl)methanone is used in drug development as a lead compound, providing a foundation for the design and optimization of new pharmaceuticals targeting various diseases and conditions.

Upstream product

• 108-86-1 bromobenzene 
• 38487-85-3 4-methoxyanthranilonitrile 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 179104-61-1 (4-methoxy-2-nitrophenyl)-phenyl-methanol 
• 1392300-36-5 4-methoxy-2-(phenylsulfonamido)benzoic acid 
• 4294-95-5 4-methoxyanthranilic acid 
• 536-90-3 m-Anisidine 
• 13740-49-3 N-(2-benzoyl-5-methoxyphenyl)acetamide 
• 588-16-9 m-methoxyacetanilide 
• 100-47-0 benzonitrile 
• 1228191-31-8 C₁₄H₁₁NO₄ 
• 13234-81-6 7-methoxy-2-methyl-4H-benzo[d][1,3]oxazin-4-one 

Downstream Products

• 5358-30-5 8-methoxy-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one 
• 174635-05-3 1,2-dihydro-7-methoxy-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester 
• 1228190-87-1 C₁₄H₁₁N₃O₂ 
• 1433904-23-4 7-methoxy-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carbonitrile 
• 1440429-60-6 C₂₈H₂₇NO₃S 
• 1440430-15-8 C₂₄H₂₃NO₃S 
• 1440429-84-4 C₁₇H₁₇NO 
• 132522-16-8 8-methoxy-1-methyl-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one 
• 102662-40-8 N-(2-benzoyl-5-methoxy-phenyl)-phthalimide 

Relevant academic research and scientific papers

Asymmetric Synthesis of Hydroquinazolines Bearing C4-Tetrasubstituted Stereocenters via Kinetic Resolution of α-Tertiary Amines

A novel protocol for asymmetric synthesis of hydroquinazolines bearing C4-tetrasubstituted stereocenters has been achieved through kinetic resolution of 2-amido α-tertiary benzylamines via chiral phosphoric acid catalyzed intramolecular dehydrative cyclizations. This method gave access to both α-tertiary benzylamines and hydroquinazolines with broad scope and high enantioselectivities. An intriguing restricted rotation of the C-N bond was observed for hydroquinazoline products bearing C4-tetrasubstituted stereocenters.

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Three-Component Approach to Pyridine-Stabilized Ketenimines for the Synthesis of Diverse Heterocycles

Ketenimines are versatile synthetic intermediates capable of performing novel transformations in organic synthesis. They are normally generated in situ due to their inherent instability and high level of reactivity. Herein, we report pyridine-stabilized ketenimine zwitterionic salts, which are prepared through click chemistry from readily accessible alkynes and sulfonyl azides. To demonstrate their synonymous reactivity to ketenimines, these salts have been utilized in a cascade sequence to access highly functionalized quinolines including the core structures of an antiprotozoal agent and the potent topoisomerase inhibitor Tas-103.

Synthesis of Diiodinated All-Carbon 3,3′-Diphenyl-1,1′-spirobiindene Derivatives via Cascade Enyne Cyclization and Electrophilic Aromatic Substitution

A synthetic method for the construction of diiodinated all-carbon spirobiindene derivatives has been developed from the reaction of propargyl alcohol-tethered alkylidenecyclopropanes with iodine. The reaction proceeded through an iodination-initiated cascade intramolecular enyne cyclization and electrophilic aromatic substitution reaction process in 1,2-dichloroethane upon heating, giving desired spirocyclic products in moderate to excellent yields. Further transformation of the obtained products has also been presented.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.

A mild and practical procedure for synthesis of substituted 2-aminobenzophenones

Abstract A convenient three-step procedure has been developed for synthesis of substituted 2-aminobenzophenones from substituted anilines. The anilines are first protected as acetanilides, by reaction with acetic anhydride. These are then benzoylated with (trichloromethyl)benzene in the presence of aluminium-generated 2-acetamidobenzophenone. Finally, removal of the acetyl group from the amino group provides the substituted 2-aminobenzophenones in moderate to good yields.

FLUOROALKYL AND FLUOROCYCLOALKYL 1,4-BENZODIAZEPINONE COMPOUNDS AS NOTCH|INHIBITORS

Disclosed are compounds of Formula (I): (Formula (I)) wherein: R1 is -CH2CH2CF3; R2 is -CH2CH2CH2F, -CH2CF2CH3, -CH2CH

NEW ARYL-QUINOLINE DERIVATIVES

The invention provides novel compounds having the general formula (I), wherein R1, R2, R3, R4 R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds.

ARYL-QUINOLINE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.