37527-70-1Relevant academic research and scientific papers
Synthesis of 2,3-dihydrobenzo[b]thiophen-3-amine 1,1-dioxide derivatives via lda-mediated cyclization of o-(alkylsulfonyl)benzyl azides with denitrogenation
Kobayashi, Kazuhiro,Chikazawa, Yuuki,Nogi, Takashi
, p. 1678 - 1692 (2017/09/20)
A new and efficient method for the synthesis of 2,3-dihydrobenzo[b]thiophen-3-amine 1,1-dioxide derivatives has been developed. Thus, treatment of o-(alkylsulfonyl)benzyl azides, which are readily obtainable from commercially available starting materials
DIHYDROPYRIMIDINE LACTONE DERIVATIVES
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, (2008/06/13)
Novel compounds of the formula STR1 wherein X is sulfur or oxygen, R 2 is aryl or heterocyclo and R 1 is as defined herein, are disclosed. Compounds of formula I possess calcium channel activating activity.
5-LIPOXYGENASE INHIBITORS
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, (2008/06/13)
This invention relates to 2-(substituted)-N-hydroxy-N-alkylcinnamamides of the formula: where R1 is C1 -C4 alkyl; n is 0 or 1; R2 is trifluoromethyl, C1 -C10 alkyl, phen(C1 -C4)alkylene or where m is 0, 1 or 2 and R3 is C1 -C4 alkyl; X is C1 -C6 alkyl, ph
Chemistry of Sulfenic Acids. 7. Reason for the High Reactivity of Sulfenic Acids. Stabilization by Intramolecular Hydrogen Bonding and Electronegativity Effects
Davis, Franklin A.,Jenkins, Linda A.,Billmers, Robert L.
, p. 1033 - 1040 (2007/10/02)
It is proposed that the reason sulfenic acids (RSOH) are so reactive and usually not isolated or even detected is that they form thiosulfinates (RS(O)SR) so readily.This is a consequence of the sulfenic acid hydrogen-bonded dimer, 1, which lowers the energy of activation for thiosulfinate formation.The stability of the few sulfenic acids that have been isolated can be explained in terms of steric, electronic, and intramolecular hydrogen-bonding effects which prevent dimer formation.The importance of these effects on the stability of simple unstable sulfenic acids was demonstrated by flash vacuum pyrolysis (FVP) and the thiosulfinate/vinyl sulfoxide ratio.A novel, high yield, rearrangement of sulfenic acid 19f to 1,3-benzothiazine 26 was observed.
