3753-27-3

Basic information

• Product Name: sodium toluene-4-thiosulphonate
• Synonyms: p-Toluenesulfonic acid, thio-, sodium salt;p-Toluenesulfonic acid, thio-, S-sodium salt;Sodium p-toluenethiosulfonate;Sodium-p-toluene-thiosulphonate;sodium toluene-4-thiosulphonate;Natriumtoluol-4-thiosulfonat;4-Methylbenzenesulfonothioic acid, sodium salt;Benzenesulfonothioic acid, 4-methyl-, sodium salt
• CAS NO: 3753-27-3
• Molecular Formula: C₇H₇O₂S₂*Na
• Molecular Weight: 210.24905
• EINECS: 223-156-3
• Mol File: 3753-27-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 341.4°Cat760mmHg
• Flash Point: 160.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.1E-05mmHg at 25°C
• CAS DataBase Reference: sodium toluene-4-thiosulphonate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium toluene-4-thiosulphonate(3753-27-3)
• EPA Substance Registry System: sodium toluene-4-thiosulphonate(3753-27-3)

Safety Data

• Hazardous Substances Data: 3753-27-3(Hazardous Substances Data)

Usage

General Description

Sodium toluene-4-thiosulphonate, also known as STS, is a chemical compound often used as a growth regulator in horticulture to improve fruit set and yield in various crops. It works by inhibiting the synthesis of ethylene, a plant hormone involved in the ripening of fruits and the senescence of flowers. STS is typically applied as a spray to the flowers or fruit clusters of plants, where it can be absorbed and affect the hormonal balance within the plant. It is considered a safe and effective way to control the development and maturation of fruits, ultimately leading to improved crop yields. However, it is important to follow proper handling and application procedures to ensure the safe and effective use of STS.

InChI:InChI=1/C7H8O2S2.Na/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10);/q;+1/p-1

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 4010-05-3 1,4-bis(p-toluenesulfonylthio)butane 
• 133795-31-0 4,8-dimethyl-3(E),7-nonadienyl 4'-methylbenzenethiosulfonate 
• 4973-66-4 methyl thiotosylate 
• 7559-53-7 n-Octyl-p-toluolthiolsulfonat 
• 271600-36-3 N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide 
• 365441-85-6 N-(tert-butoxycarbonyl)-1-tosyleth-1-ylamine 
• 155212-94-5 S-[(4-methoxyphenyl)methyl] 4-methylbenzene-1-sulfonothioate 
• 169601-69-8 S-(3-phenylpropyl) 4-methylbenzenesulfonothioate 

Relevant articles and documents

Transition-Metal-Free Synthesis of Unsymmetrical Disulfides via Three-Component Reaction of Thiosulfonates, Thiourea and Alkyl halides

A transition-metal-free approach to synthesize unsymmetrical disulfides is reported that relies on a K2CO3-promoted one-pot reaction of thiosulfonates, thiourea and alkyl halides under mild conditions. The protocol tolerates a wide range of substrates, leading to various types of unsymmetrical disulfides in moderate to excellent yields. More importantly, the late-stage modification of natural products and drug molecules was also achieved. (Figure presented.).

Cs2CO3-Mediated Vicinal Thiosulfonylation of 1,1-Dibromo-1-Alkenes with Thiosulfonates: An Expedient Synthesis of (E)-1,2-Thiosulfonylethenes

A new and highly efficient vicinal thiosulfonylation of 1,1-dibromo-1-alkenes with thiosulfonates in the presence of cesium carbonate has been developed. The metal-free diheterofunctionalization is an operationally simple to access a wide range of (E)-1,2-thiosulfonylethenes (α-aryl-β-thioarylvinyl sulfones) in moderate to high yields with high levels of stereoselectivities. Further, scalable reactions have been demonstrated for this transformation, thus illustrating its efficiency and practicality. (Figure presented.).

EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.