17046-97-8

Upstream product

• 14756-51-5 4-nitrophenyl p-tolyl disulfide 
• 28519-50-8 potassium thiotosylate 
• 63296-21-9 methyl 4-nitrophenyl disulphide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 3753-27-3 sodium 4-methylbenzenesulfonothioate 
• 1849-36-1 para-nitrobenzenethiol 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 17796-89-3 1-[(4-nitrophenyl)sulfanyl]pyrrolidine-2,5-dione 
• 937-32-6 4-nitrobenzenesulfenyl chloride 
• 100-32-3 di(p-nitrophenyl) disulfide 

Downstream Products

• 60094-81-7 1-[(4-nitrophenyl)thio]piperidine 
• 39248-99-2 S-(4-nitrophenyl) 4-methylbenzothioate 

Relevant academic research and scientific papers

Organocatalytic Transformation of Aldehydes to Thioesters with Visible Light

A metal- and oxidant-free catalytic method for accessing structurally diverse thioesters from readily accessible, widespread aldehydes, is described. A strategy of a simple organic 9,10-phenanthrenequinone-promoted hydrogen atom transfer (HAT) with visible light was successfully implemented to selectively generate acyl radicals without inducing crossover reactivity of thioester products. The preparative power of the method was demonstrated by broad substrate scope and wide functional group tolerance, and enabled the late-stage modification of complex structures, which are difficult to achieve with the existing protocols.

Metal-Free Synthesis of Thiosulfonates via Insertion of Sulfur Dioxide

A simple and catalyst-free strategy was developed for the synthesis of unsymmetrical thiosulfonates using readily available DABCO?(SO2)2 as a solid and bench-stable sulfur dioxide surrogate. The corresponding thiosulfonates were obtained through a radical pathway with good functional group tolerance. This strategy offers a promising synthesis method for the construction of diverse and useful thiosulfonates in the field of synthetic and pharmaceutical chemistry and extends the number of still limited sulfur dioxide fixation strategies. (Figure presented.).

Method for synthesizing thiosulfonate compounds on the basis of strategy of SO2 insertion

The invention relates to a method for synthesizing thiosulfonate compounds on the basis of strategy of SO2 insertion. The method includes: performing a reaction in the presence of nitrogen gas and atcertain temperature to prepare the thiosulfonate compoun

Copper-Catalyzed TBHP-Mediated Radical Cross-Coupling Reaction of Sulfonylhydrazides with Thiols Leading to Thiosulfonates

A tert-butyl hydroperoxide (TBHP)-mediated coupling of sulfonylhydrazides with thiols catalyzed by CuBr2 to afford thiosulfonates via a radical process is described.

Tunable and Practical Synthesis of Thiosulfonates and Disulfides from Sulfonyl Chlorides in the Presence of Tetrabutylammonium Iodide

A tunable and practical synthesis of electrophilic sulfenylating reagents, thiosulfonates and disulfides, from inexpensive and easily available sulfonyl chlorides, has been developed. By appropriate choice of solvents, the reaction of sulfonyl chlorides and tetrabutylammonium iodide gave the target products in good to excellent yields, respectively. These transformations probably proceed through a reducing–coupling pathway. (Figure presented.).

Oxidative coupling of dichalcogenides with sodium sulfinates via copper-catalyzed cleavage of s-s and se-se bonds

A copper-catalyzed sulfonylation of disulfides was achieved using sodium sulfinates in air. The reaction formed various sulfur-sulfone bonds efficiently and afforded thiosulfonates in good yields. Selenosulfonates could also be prepared with this procedure. Furthermore, both chalcogenide groups on the dichalcogenides were available in these reactions.

Sc(OTf)3-catalyzed synthesis of thiosulfonates in ionic liquid-water

The first example of Sc(OTf)3-catalyzed sulfenylation of sodium sulfinates with N-(organothio)succinimides in ionic liquids (ILs) and water cosolvent system was developed, achieving thiosulfonates in moderate to excellent yields. Additionally, Sc(OTf)3/ILs could be recovered easily after the reactions and reused without a significant loss in the catalytic activity. Thus, the present protocol represents an interesting complement to known methods for thiosulfonates synthesis.

Sulfur containing compounds

This invention is directed to novel and known stufur containing compounds and pharmaceutically acceptable salts thereof that have utility as antifungals and as antiproliferative agents against mammalian cells, in particular cancer cells and most particularly leukemia-derived cells. The invention provides a method for synthesizing certain of the sulfur containing compounds that is more efficient than previously known methods.

Antifungal thiosulfonates: Potency with some selectivity

A series of thiosulfonates have been prepared and tested against Aspergillus niger and Aspergillus flavus. In general, the thiosulfonates are moderate antifungal agents - more potent than corresponding inactive disulfides and less potent than corresponding very active fungitoxic disulfides. A pair of thiosulfonates show high selectivity, each killing only one kind of fungus. CSIRO 2000.

Hypervalent iodine in synthesis. XXII: A novel way for the preparation of unsymmetric S-aryl thiosulfonates by the reaction of potassium thiosulfonates with diaryliodonium salts

Unsymmetric S-aryl thiosulfonates can be generated through a novel way for the reaction of potassium thiosulfonates with diaryliodonium salts in good yields under mild conditions.