37532-04-0

Basic information

• Product Name: N'-(2,6-dichlorobenzylidene)-4-methylbenzene-1-sulfonohydrazide
• Synonyms: N'-(2,6-dichlorobenzylidene)-4-methylbenzene-1-sulfonohydrazide
• CAS NO: 37532-04-0
• Molecular Weight: 343.233
• Mol File: 37532-04-0.mol

Chemical Properties

• CAS DataBase Reference: N'-(2,6-dichlorobenzylidene)-4-methylbenzene-1-sulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(2,6-dichlorobenzylidene)-4-methylbenzene-1-sulfonohydrazide(37532-04-0)
• EPA Substance Registry System: N'-(2,6-dichlorobenzylidene)-4-methylbenzene-1-sulfonohydrazide(37532-04-0)

Safety Data

• Hazardous Substances Data: 37532-04-0(Hazardous Substances Data)

Upstream product

• 83-38-5 2,6-dichlorobenzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 50-30-6 2,6-dichlorobenzoic acid 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 1310207-71-6 3-(2,6-dichlorophenyl)-1H-indazole 
• 32188-71-9 2,6-dichlorobenzaldehyde (2,6-dichlorobenzylidene)hydrazone 
• 1356571-82-8 2-butoxymethyl-1,3-dichlorobenzene 
• 694525-13-8 2,6-dichlorobenzyl benzoate 
• 1400741-60-7 2,6-dichlorophenyl (O,1-⁽²⁾H₂)methanol 
• 15258-73-8 2,6-dichlorobenzyl alcohol 
• 1403770-37-5 2-(2,6-dichlorobenzyl)benzofuran 
• 1190707-28-8 1,3-dichloro-2-(prop-1-yn-1-yl)benzene 
• 76089-72-0 (Z)-1,3-dichloro-2-styrylbenzene 
• 25144-42-7 (E)-1,3-dichloro-2-styrylbenzene 

Relevant articles and documents

Synthesis of 1,2-diarylethylenes by Pd-catalyzed one-pot reaction of benzyl halides, tosylhydrazide, and aryl aldehydes

Background: Substituted olefins are versatile functional groups and intermediates in chemistry, medicine, electronics, and optics and materials science fields because of their unique properties. One important class of substituted olefins 1,2-diarylethylenes have attracted considerable attention due to their presence in both natural products and pharmacologically active substances. Methods: In this paper, we developed a one-pot two-step coupling reaction of aryl aldehydes, tosylhydrazide with benzyl halides by using inexpensive Pd(PPh3)4 as catalyst, leading to a variety of 1,2- diphenylethenes derivatives with moderate to good yields. Results: The desired 1,2-diarylethylenes were obtained in 46-96% yields via Pd(0)-catalyzed one-pot reaction of benzyl halides, tosylhydrazide, and aryl aldehydes. Conclusion: The catalytic system presented here enables the use of easily accessible starting materials and good functional group tolerance.

Synthesis of substituted 1 H-indazoles from arynes and hydrazones

The 1H-indazole skeleton can be constructed by a [3 + 2] annulation approach from arynes and hydrazones. Under different reaction conditions, both N-tosylhydrazones and N-aryl/alkylhydrazones can be used to afford a variety of indazoles. The former reaction affords 3-substituted indazoles either via in situ generated diazo compounds or through an annulation/elimination process. The latter reaction leads to 1,3-disubstituted indazoles likely through an annulation/oxidation process. The reactions operate under mild conditions and can accommodate aryl, vinyl, and less satisfactorily, alkyl groups.

Synthesis of 3-substituted indazoles from arynes and N-tosylhydrazones

Readily available, stable, and inexpensive N-tosylhydrazones react with arynes under mild reaction conditions to afford 3-substituted indazoles in moderate to good yields. The reaction appears to involve a dipolar cycloaddition of in situ generated diazo