37538-65-1

Basic information

• Product Name: Pyrido[2,3-d]pyrimidin-4-amine (9CI)
• Synonyms: Pyrido[2,3-d]pyrimidin-4-amine (9CI);Pyrido[2,3-d]pyrimidin-4-amine
• CAS NO: 37538-65-1
• Molecular Formula: C7H6N4
• Molecular Weight: 146.14934
• Product Categories: PYRIMIDINE
• Mol File: 37538-65-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 305-310 °C (decomp)(Solv: ethanol (64-17-5))
• Boiling Point: 349.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.385±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.97±0.30(Predicted)
• CAS DataBase Reference: Pyrido[2,3-d]pyrimidin-4-amine (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-d]pyrimidin-4-amine (9CI)(37538-65-1)
• EPA Substance Registry System: Pyrido[2,3-d]pyrimidin-4-amine (9CI)(37538-65-1)

Safety Data

• Hazardous Substances Data: 37538-65-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 1695, 1979 DOI: 10.1021/jo01324a024

Upstream product

• 91808-90-1 4-amino-1H-pyrido[2,3-d]pyrimidine-2-thione 
• 1093963-85-9 2-amino-6-(methylthio)nicotinonitrile 
• 68640-74-4 2-amino-N’-hydroxynicotinimidamide 
• 122-51-0 orthoformic acid triethyl ester 
• 28732-79-8 4-chloro-pyrido[2,3-d]pyrimidine 
• 21038-66-4 1H-Pyrido[2,3-d]pyrimidine-2,4-dione 
• 1508-07-2 1,1-dicyanopropene 
• 1350452-23-1 2-(1-(trimethylsilyl)ethylidene)malononitrile 
• 91996-74-6 1H-pyrido[2,3-d]pyrimidine-2,4-dithione 
• 126728-20-9 2,4-dichloropyrido[2,3-d]pyrimidine 
• 91448-10-1 4-amino-2-chloropyrido[2,3-d]pyrimidine 
• 24410-19-3 3H-pyrido[2,3-d]pyrimidin-4-one 
• 7463-30-1 N-(2-pyridyl-3-methyl)acetamide 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 

Relevant articles and documents

Modular assembly of purine-like bisphosphonates as inhibitors of hiv-1 reverse transcriptase

Bisphosphonates can mimic the pyrophosphate leaving group of the nucleotidyl transfer reaction and effectively inhibit RNA/DNA polymerases. In a search of HIV-1 reverse transcriptase (RT) inhibitors, a new chemotype of nonhydrolyzable purine diphosphate mimic was synthesized. A modular synthetic protocol was developed, utilizing 2-amino-6-(methylthio)-4-(trimethylsilyl)nicotinonitrile as the key synthon in the preparation of highly substituted 2-aminonicotinonitriles. These building blocks were subsequently elaborated to the pyrido[2,3-d]pyrimidine bisphosphonates (PYPY-BPs). Biochemical screening identified analogs of PYPY-BPs that inhibit HIV-1 RT-catalyzed DNA synthesis.