37554-40-8

Usage

Uses

Anti-inflammatory.

InChI:InChI=1/C16H10ClF3N2O/c17-11-6-7-13-12(8-11)14(10-4-2-1-3-5-10)21-15(23)22(13)9-16(18,19)20/h1-8H,9H2

Upstream product

• 108-20-3 di-isopropyl ether 
• 51-79-6 urethane 
• 22753-80-6 5-chloro-2-[(2,2,2-trifluoroethyl)amino]benzophenone 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 4797-43-7 6-chloro-4-phenyl-2-quinazolinone 
• 36943-01-8 6-chloro-4-phenyl-1-(2,2,2-trifluoro-ethyl)-3,4-dihydro-1H-quinazolin-2-one 
• 75-44-5 phosgene 
• 497-19-8 sodium carbonate 

Relevant academic research and scientific papers

Analgesic and myotonolytic preparations

Compositions having enhanced analgesic and myotonolytic activity comprising as active agents (a) an analeptically active quinazolinone and (b) a centrally acting myotonolytic.

Process for preparing 2(1H)-quinazolinone derivatives

2(1H)-Quinazolinone and quinazolinethione derivatives having excellent pharmacological activities are produced in high yield with high purity by heating the corresponding 3,4-dihydro-2(1H)-quinazolinone or quinazolinethione derivatives together with sulfur in an inert solvent.

1-Polyhaloalkyl-2(1H)-quinazolinone derivatives

1-Polyhaloalkyl-2(1H)-quinazoline derivatives of the formula, STR1 wherein R is polyhaloalkyl having C2 -C4 alkyl; and R1, R2 and R3 are individually hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy, nitro, trifluoromethyl or halogen, have excellent anti-inflammatory and analgesic activities with very low toxicity. These quinazolinone derivatives can be prepared, for example, by reacting a trihalogenoacetamidobenzophenone derivative with ammonia.

Production of quinazolinone compounds

2(1H)-Quinazolinone derivatives, which are useful as anti-inflammatory agents, are prepared by heating or hydrolyzing an acylurea derivative. The acylurea derivative can be prepared by either reacting an indole derivative with an oxidizing agent or reacti

Process for preparing quinazolines

Quinazoline derivatives which have anti-inflammatory, antiviral, uricosuric activities are prepared by reacting an indole-2-carbonylazide derivative with an oxidizing agent under mild conditions.