37555-99-0

Basic information

• Product Name: 2-ETHOXY-MALONIC ACID DIETHYL ESTER
• Synonyms: 2-ETHOXY-MALONIC ACID DIETHYL ESTER;ethoxy-malonic acid diethyl ester;diethyl 2-ethoxymalonate;Diethyl ethoxymalonate;Ethoxypropanedioic acid diethyl ester;1,3-diethyl 2-ethoxypropanedioate;2-Hydroxydiethyl Malonate;Propanedioic acid, 2-ethoxy-, 1,3-diethyl ester
• CAS NO: 37555-99-0
• Molecular Formula: C₉H₁₆O₅
• Molecular Weight: 204.22
• Mol File: 37555-99-0.mol

Chemical Properties

• Boiling Point: 261℃
• Flash Point: 108℃
• Appearance: /
• Density: 1.070
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-ETHOXY-MALONIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHOXY-MALONIC ACID DIETHYL ESTER(37555-99-0)
• EPA Substance Registry System: 2-ETHOXY-MALONIC ACID DIETHYL ESTER(37555-99-0)

Safety Data

• Hazardous Substances Data: 37555-99-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Ethoxy-malonic acid diethyl ester is used as an intermediate in the synthesis of pharmaceuticals for its ability to participate in various chemical reactions, contributing to the development of new drugs and medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Ethoxy-malonic acid diethyl ester serves as an intermediate in the production of agrochemicals, aiding in the synthesis of compounds that are used in crop protection and other agricultural applications.
Used in Dye Industry:
2-Ethoxy-malonic acid diethyl ester is utilized as a building block in the dye industry, where it is involved in the synthesis of various dyes used in different applications, such as textiles and printing.
Used in Organic Synthesis:
As a reagent in organic synthesis, 2-Ethoxy-malonic acid diethyl ester is used for the preparation of various esters and carboxylic acids, showcasing its versatility in chemical reactions and its importance in the synthesis of complex organic molecules.
Safety Note:
It is crucial to handle 2-Ethoxy-malonic acid diethyl ester with care, as it can be harmful if ingested, inhaled, or comes into contact with the skin or eyes. Proper safety measures should be taken during its use to minimize potential health risks.

InChI:InChI=1S/C9H16O5/c1-4-12-7(8(10)13-5-2)9(11)14-6-3/h7H,4-6H2,1-3H3

Upstream product

• 63124-37-8 2-ethoxy-3-oxo-succinic acid diethyl ester 
• 141-52-6 sodium ethanolate 
• 685-87-0 Diethyl 2-bromomalonate 
• 5256-74-6 1,3-diethyl 2-diazopropanedioate 
• 60-29-7 diethyl ether 
• 817-95-8 ethyl 2-ethoxyethanoate 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 13370-13-3 ethoxy-malonic acid-dianilide 
• 111297-65-5 4-ethoxy-5-hydroxy-1,2-diphenyl-1,2-dihydro-pyrazol-3-one 
• 344298-07-3 5-Ethoxy-2-methylamino-1H-pyrimidine-4,6-dione 
• 108720-24-7 4-ethoxy-1,2-diphenyl-pyrazolidine-3,5-dione 
• 343-67-9 ethyl 2-(trifluoromethyl)-1,6-dihydro-6-oxopyrimidine-5-carboxylate 
• 304693-56-9 ethyl 2-(4-chlorophenyl)-4-chloropyrimidine-5-carboxylate 
• 304693-58-1 ethyl 2-(4-chlorophenyl)pyrimidine-5-carboxylate 
• 56406-33-8 eEthyl 2-(4-chlorophenyl)-4-oxopyrimidine-5-carboxylate 
• 81153-44-8 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 19743-76-1 4-chloro-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 53554-29-3 ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate 
• 1313721-00-4 5-ethoxy-6-hydroxy-2-(4-nitrophenyl)-3H-pyrimidin-4-one 

Relevant articles and documents

NOVEL PYRIMIDINE COMPOUNDS AS MTOR AND P13K INHIBITORS

The present invention relates to pyrimidine compounds of formula (I): which are useful in treating mTOR kinase- or PI3K kinase-related diseases.

Use of malonic acid derivative compounds for retarding plant growth

This invention relates to a method for retarding plant growth by applying to the plant an effective amount of a malonic acid derivative compound. This invention also relates to novel malonic acid derivative compounds and processes for the preparation thereof.

Synergistic plant growth regulator compositions

This invention relates to synergistic plant growth regulator compositions containing (1) an ethylene response or ethylene-type response inducing agent and (11) a malonic acid derivative compound. This invention also relates to the use of said compositions

The Reactivity of Carbenes from Photolysis of Diazo-Compounds towards Carbon-Hydrogen Bonds. Effects of Structure, Temperature, and Matrix on the Insertion Selectivity

Direct and/or sensitized photolyses of diazo-acetate (1a) and -malonate (1b) in hydrocarbons and ether were investigated at various temperatures in order to learn more about the nature of the C-H insertion process and the structural factors governing positional selectivity within the matrix.Photolysis of the diazo-compounds in a rigid matrix resulted in a marked decrease in the insertion selectivity, which may be interpreted as indicating that the matrix imposes severe steric demand especially on the direct C-H insertion process of the singlet carbene.The addition of a sensitizer in matrix photolysis causes a marked increase in the selectivity in the case of (1a), as is observed in the comparable liquid-phase experiment, but it causes a decrease in the case of (1b).This is interpreted as suggesting that the excited triplet (1b) itself is involved in C-H insertion under these conditions.More extensive temperature studies show that, as the temperature decreases, the C-H insertion selectivity of :CHCO2R decreases regularly regardless of the reaction phase, whereas that of :C(CO2R)2 increases in the liquid phase but decreases in the solid phase.This difference in the temperature dependence is explained by assuming that the singlet carbene is responsible for the C-H insertion of :CHCO2R throughout the temperature range studied, while both singlet and triplet are involved in the insertion of :C(CO2R)2.

Analgesics. 2. Selected 5 substituted 5 (1 phenylethyl)barbituric acids

Several 5 substituted 5 (1 phenylethyl)barbituric acids displayed potent analgesic activity. One compound, 5 acetoxy 5 (1 phenylethyl)barbituric acid, exhibited better analgesic activity than codeine orally and had one thirds of the analgesic potency of morphine when administered subcutaneously. Another compound, 5 cyclopropylcarbonyloxy 5 (1 (phenylethyl)barbituric acid, exhibited better analgesic activity than codeine orally and was approximately 10 times as potent as morphine when administered subcutaneously. Three other compounds also revealed better analgesic activity than codeine orally.