37586-00-8

Usage

InChI:InChI=1/C13H11N3O3/c1-9-3-2-4-12(14-9)15-13(17)10-5-7-11(8-6-10)16(18)19/h2-8H,1H3,(H,14,15,17)

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 122-04-3 4-nitro-benzoyl chloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 686290-07-3 [N-(6-methyl-2-pyridyl)-4-nitrobenzamide]dinickel(II) di-μ-bromide dibromide 
• 36845-08-6 2-(4-aminobenzoylamino)-6-methyl-pyridine 

Relevant academic research and scientific papers

Compositional Persistence in a Multicyclic Network of Synthetic Replicators

The emergence of collections of simple chemical entities that create self-sustaining reaction networks, embedding replication and catalysis, is cited as a potential mechanism for the appearance on the early Earth of systems that satisfy minimal definitions of life. In this work, a functional reaction network that creates and maintains a set of privileged replicator structures through auto- A nd cross-catalyzed reaction cycles is created from the pairwise combinations of four reagents. We show that the addition of individual preformed templates to this network, representing instructions to synthesize a specific replicator, induces changes in the output composition of the system that represent a network-level response. Further, we establish through sets of serial transfer experiments that the catalytic connections that exist between the four replicators in this network and the system-level behavior thereby encoded impose limits on the compositional variability that can be induced by repeated exposure to instructional inputs, in the form of preformed templates, to the system. The origin of this persistence is traced through kinetic simulations to the properties and inter-relationships between the critical ternary complexes formed by the auto- A nd crosscatalytic templates. These results demonstrate that in an environment where there is no continuous selection pressure the network connectivity, described by the catalytic relationships and system-level interactions between the replicators, is persistent, thereby limiting the ability of this network to adapt and evolve.

Compositional Persistence in a Multicyclic Network of Synthetic Replicators

The emergence of collections of simple chemical entities that create self-sustaining reaction networks, embedding replication and catalysis, is cited as a potential mechanism for the appearance on the early Earth of systems that satisfy minimal definitions of life. In this work, a functional reaction network that creates and maintains a set of privileged replicator structures through auto- and cross-catalyzed reaction cycles is created from the pairwise combinations of four reagents. We show that the addition of individual preformed templates to this network, representing instructions to synthesize a specific replicator, induces changes in the output composition of the system that represent a network-level response. Further, we establish through sets of serial transfer experiments that the catalytic connections that exist between the four replicators in this network and the system-level behavior thereby encoded impose limits on the compositional variability that can be induced by repeated exposure to instructional inputs, in the form of preformed templates, to the system. The origin of this persistence is traced through kinetic simulations to the properties and inter-relationships between the critical ternary complexes formed by the auto- and crosscatalytic templates. These results demonstrate that in an environment where there is no continuous selection pressure the network connectivity, described by the catalytic relationships and system-level interactions between the replicators, is persistent, thereby limiting the ability of this network to adapt and evolve.

Water templated hydrogen-bonded network of pyridine amide appended carbamate in solid state

The pyridine amide appended carbamates 1 and 2 have been synthesized and their hydrogen-bonded self-assemblies in solid state have been described. The self-association pattern is dependent on the nature the anchored group of the carbamate moiety and influ

Synthesis and characterization of N-(2-pyridyl)benzamide-based nickel complexes and their activity for ethylene oligomerization

A series of N-(2-pyridyl)benzamides (1)-(11) and their nickel complexes, [N-(2-pyridyl)benzamide]dinickel(II) di-μ-bromide dibromide (12)-(16) and (aryl)[N-(2-pyridyl)benzamido] (triphenylphosphine)nickel(II) (17)-(24), were synthesized and characterized.

Troger's base molecular scaffolds in dicarboxylic acid recognition

Artificial receptors (1-5) have been designed and synthesized from simple precursors. The chain length selectivity studies of dicarboxylic acids within the cavities of new fluorescent Troger's base molecular frameworks (1- 3) have been carried out with a critical examination of their role of rigidity as well as flexibility in selective binding in comparison to receptor 5. The chiral resolution of the racemic Troger's base receptors (1 and 2) by chiral recognition with (+)- camphoric acid using hydrogen-bonding interactions has been studied.

Molecular recognition: Chain length selectivity studies of dicarboxylic acids by the cavity of a new Troger's base receptor

A new dicarboxylic acid receptor 1 having two pyridine amide motifs built on a Troger's base spacer has been designed and synthesised. The binding studies are performed with a series or dicarboxylic acids and the cavity of receptor 1 was found to be selec

Molecular recognition: Connection and disconnection of hydrogen bonds, a case study with dimeric and highly associated monocarboxylic acids with simple receptors

The new receptor (5) having mixed diamide moieties is a simple synthetic model which binds carboxylic acids by three point hydrogen bonds involving pyridine nitrogen, pyridine amide as well as the flexible aliphatic amide moieties. This is in contrast to