37599-60-3Relevant academic research and scientific papers
Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Young, Robert J.,Borthwick, Alan D.,Brown, David,Burns-Kurtis, Cynthia L.,Campbell, Matthew,Chan, Chuen,Charbaut, Marie,Convery, Maire A.,Diallo, Hawa,Hortense, Eric,Irving, Wendy R.,Kelly, Henry A.,King, N. Paul,Kleanthous, Savvas,Mason, Andrew M.,Pateman, Anthony J.,Patikis, Angela N.,Pinto, Ivan L.,Pollard, Derek R.,Senger, Stefan,Shah, Gita P.,Toomey, John R.,Watson, Nigel S.,Weston, Helen E.,Zhou, Ping
, p. 28 - 33 (2008/09/17)
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activities and encouraging oral pharmacokinetic profiles.
