3920-50-1

Basic information

• Product Name: 2H-PYRAZOLE-3-CARBALDEHYDE
• Synonyms: PYRAZOLE-3-CARBALDEHYDE;RARECHEM AM LA 0023;1H-PYRAZOLE-5-CARBALDEHYDE;1H-PYRAZOLE-3-CARBXALDEHYDE;1H-PYRAZOLE-3-CARBALDEHYDE;2H-PYRAZOLE-3-CARBALDEHYDE;2H-PYRAZOLE-3-CARBOXALDEHYDE;Pyrazole-3-carboxaldehyde
• CAS NO: 3920-50-1
• Molecular Formula: C₄H₄N₂O
• Molecular Weight: 96.08736
• Mol File: 3920-50-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 149.0 to 153.0 °C
• Boiling Point: 299.984 °C at 760 mmHg
• Flash Point: 139.672 °C
• Appearance: /
• Density: 1.323
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.20±0.10(Predicted)
• CAS DataBase Reference: 2H-PYRAZOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-PYRAZOLE-3-CARBALDEHYDE(3920-50-1)
• EPA Substance Registry System: 2H-PYRAZOLE-3-CARBALDEHYDE(3920-50-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 3920-50-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless Solid

Uses

1H-?Pyrazole-?3-?carboxaldehyde is an intermediate used to prepare fused pyrrole carboxylic acids as novel, potent D-?amino acid oxidase (DAO) inhibitors. It is also a building block to synthesize α-?substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2?/neu tyrosine kinases.

InChI:InChI=1/C4H4N2O/c7-3-4-1-2-5-6-4/h1-3H,(H,5,6)

Upstream product

• 186581-53-3 diazomethane 
• 624-67-9 Propargylic aldehyde 
• 23585-49-1 (1H-pyrazol-3-yl)methanol 
• 111573-59-2 pyrazole-3-carboxaldehyde dimethylacetal 

Downstream Products

• 415912-15-1 2-{4-[6-chloro-2-(1H-pyrazol-3-yl)-5-(trifluoromethyl)-1H-benzimidazol-1-yl]phenyl}ethanol 
• 321405-31-6 1-benzyl-1H-pyrazole-3-carbaldehyde 
• 37599-60-3 C₆H₁₁N₃ 
• 1201677-80-6 C₂₄H₃₀N₄O₂S 
• 1201677-82-8 C₂₁H₂₄N₄O₂S 
• 1201677-83-9 C₂₁H₂₁N₅O₂S 
• 1201677-85-1 C₂₀H₂₁ClN₄O₂S 
• 1201677-86-2 C₂₁H₂₃ClN₄O₂S 
• 1201677-87-3 C₂₆H₂₆N₄O₂S 
• 1201677-88-4 C₂₃H₂₈N₄O₃S 
• 27258-32-8 1-methyl-1H-pyrazole-3-carbaldehyde 
• 1621-91-6 1H-pyrazole-3-carboxylic acid 
• 1621-91-6 1-2H-pyrazole-3-carboxylic acid 
• 911491-41-3 C₂₁H₂₃FN₆O₃ 

Relevant articles and documents

Synthetic method of tert-butyl-7-hydroxy-7,8-dihydro-4H-pyrazolo [1,5-a][1,4] diazepin-5-(6H)-carboxylate

The invention relates to a synthetic method of tert-butyl-7-hydroxy-7,8-dihydro-4H-pyrazolo [1,5-a][1,4] diazepin-5-(6H)-carboxylate and mainly solves the technical problems of low perfect ratio of a route, difficulty in reaction control, inconvenience in experiment operation and the like in the conventional synthetic process. Tert-butyl-7-hydroxy-7,8-dihydro-4H-pyrazolo [1,5-a][1,4] diazepin-5-(6H)-carboxylate is prepared from 1,1-dimethoxypropane-2-one serving as a starting material through six steps of reactions. The equation is shown in the specification. The obtained product diazepine is a useful intermediate or product for synthesis of various drugs.

Highly active binuclear Cu(II) catalyst bearing an unsymmetrical bipyridine-pyrazole-amine ligand for the azide-alkyne cycloaddition reaction

Ligands containing NH groups often show special characteristics. In this paper, a well-defined dinuclear Cu(II) complex bearing an unsymmetrical bipyridine-pyrazole-amine ligand was synthesized by the condensation of N–H to release H2O. Using sodium L-ascorbate as a reductant, the binuclear complex showed excellent activity in 1,3-dipolar cycloaddition reactions between alkynes and azides to obtain 1,4-disubstituted triazoles in 95%–99% isolated yields.

Acetylenic 1,5-diarylpyrazoles as antiinflammatory agents

Compounds of Formula I STR1 wherein, R1 through R7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment of inflamm