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3920-50-1

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3920-50-1 Usage

Description

2H-PYRAZOLE-3-CARBALDEHYDE, also known as 1H-Pyrazole-3-carboxaldehyde, is an organic compound with the chemical formula C4H3N2O. It is a colorless solid and serves as a crucial intermediate in the synthesis of various biologically active molecules. Its structure features a pyrazole ring with a formyl group attached to the third position, which allows for further chemical modifications and the creation of diverse compounds with potential applications in pharmaceuticals and other industries.

Uses

Used in Pharmaceutical Industry:
2H-PYRAZOLE-3-CARBALDEHYDE is used as an intermediate for the preparation of fused pyrrole carboxylic acids, which are novel and potent inhibitors of D-amino acid oxidase (DAO). These inhibitors play a significant role in the development of treatments for various neurological disorders and conditions related to the imbalance of D-amino acids in the body.
2H-PYRAZOLE-3-CARBALDEHYDE is also used as a building block in the synthesis of α-substituted benzylidenemalononitrile tyrphostins. These compounds are potent inhibitors of the EGF receptor and ErbB2/neu tyrosine kinases, which are overexpressed in various types of cancer cells. By targeting these receptors, these inhibitors can potentially be used in the development of anticancer drugs, particularly for solid malignancies such as liver, breast, lung, pancreatic, colorectal, and ovarian cancers.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2H-PYRAZOLE-3-CARBALDEHYDE serves as a versatile building block for the creation of a wide range of compounds with diverse applications. Its reactivity and functional groups allow for various chemical reactions, such as condensation, substitution, and reduction, enabling the synthesis of novel molecules with potential uses in different industries, including pharmaceuticals, agrochemicals, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 3920-50-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,2 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3920-50:
(6*3)+(5*9)+(4*2)+(3*0)+(2*5)+(1*0)=81
81 % 10 = 1
So 3920-50-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H4N2O/c7-3-4-1-2-5-6-4/h1-3H,(H,5,6)

3920-50-1Relevant articles and documents

Synthetic method of tert-butyl-7-hydroxy-7,8-dihydro-4H-pyrazolo [1,5-a][1,4] diazepin-5-(6H)-carboxylate

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Paragraph 0008, (2017/10/22)

The invention relates to a synthetic method of tert-butyl-7-hydroxy-7,8-dihydro-4H-pyrazolo [1,5-a][1,4] diazepin-5-(6H)-carboxylate and mainly solves the technical problems of low perfect ratio of a route, difficulty in reaction control, inconvenience in experiment operation and the like in the conventional synthetic process. Tert-butyl-7-hydroxy-7,8-dihydro-4H-pyrazolo [1,5-a][1,4] diazepin-5-(6H)-carboxylate is prepared from 1,1-dimethoxypropane-2-one serving as a starting material through six steps of reactions. The equation is shown in the specification. The obtained product diazepine is a useful intermediate or product for synthesis of various drugs.

Highly active binuclear Cu(II) catalyst bearing an unsymmetrical bipyridine-pyrazole-amine ligand for the azide-alkyne cycloaddition reaction

Han, Baofeng,Xiao, Xiao,Wang, Lan,Ye, Wenjing,Liu, Xiaoping

, p. 1446 - 1450 (2016/10/04)

Ligands containing NH groups often show special characteristics. In this paper, a well-defined dinuclear Cu(II) complex bearing an unsymmetrical bipyridine-pyrazole-amine ligand was synthesized by the condensation of N–H to release H2O. Using sodium L-ascorbate as a reductant, the binuclear complex showed excellent activity in 1,3-dipolar cycloaddition reactions between alkynes and azides to obtain 1,4-disubstituted triazoles in 95%–99% isolated yields.

Acetylenic 1,5-diarylpyrazoles as antiinflammatory agents

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, (2008/06/13)

Compounds of Formula I STR1 wherein, R1 through R7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment of inflamm

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