37629-77-9

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 2460-33-5 3,4-dimethoxyphenylpyruvic acid 

Downstream Products

• 74272-62-1 10-cyano-2,3,6-trimethoxyphenanthrene 
• 1150647-81-6 (E)-α-(3,4-dimethoxyphenyl)-4-methoxycinnamonitrile 
• 114651-98-8 (E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde 
• 1346463-56-6 4-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)penta-(2E,4Z)-dienoyl azide 
• 1346463-43-1 4-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)penta-(2E,4Z)-dienoic acid 
• 1346463-84-0 (Z)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde 
• 102473-35-8 3-(3,4-dimethoxy-phenyl)-4-(4-methoxy-phenyl)-3-methyl-hexan-2-one 

Relevant academic research and scientific papers

Cyano Group Removal from Cyano-Promoted Aza-Diels-Alder Adducts: Synthesis and Structure-Activity Relationship of Phenanthroindolizidines and Phenanthroquinolizidines

Phenanthroindolizidines and phenanthroquinolizidines were concisely synthesized by the reductive decyanization of cyano-promoted intramolecular aza-Diels-Alder cycloadducts followed by aryl-aryl coupling. Cyano groups were removed from α-aminoacrylonitriles via treatment with sodium borohydride in 2-propanol in almost quantitative yields; a possible mechanism was proposed and examined using D-labeling experiments. A systematic study of the effects of the phenanthrene substitution pattern on the anticancer activity against three human cancer cell lines was discussed. (Chemical Equation Presented).

Substituent effects on the iodine-catalyzed thermal cyclization of 3,4-diphenylbuta-1,3-dienyl isocyanates: Mechanistic studies

The thermal cyclization of 3,4-diphenylbuta-1,3-dienyl isocyanates 1, generated in situ from the corresponding azides, was investigated using iodine as a catalyst. Diphenylpyridinones 2, phenylnaphthalenes 3, and indenes 4 were produced via intramolecular ring closure. The nature of the substituents on the phenyl rings was found to be crucial to the distribution of cyclized products 2 - 4. The mechanism of the reaction is also discussed.

Synthesis of phenanthro[9,10-b]indolizidin-9-ones, phenanthro[9,10-b] quinolizidin-9-one, and related benzolactams by Pd(OAc)2-catalyzed direct aromatic carbonylation

Phenanthro[9,10-b]indolizidin-9-ones, phenanthro[9,10-b]-quinolizidin-9- one, and related benzolactams were synthesized by benzolactam ring formation using Pd(OAc)2-catalyzed direct aromatic carbonylation. This also constitutes a formal synthesis of the representative phenanthroindolizidine and -quinolizidine alkaloids (±)-tylophorine, (±)-antofine, and (±)-cryptopleurine. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

Synthesis, characterisation and photophysical properties of a,a-diaryl-acrylonitrile derivatives

a,b-Diarylacrylonitrile derivatives can be prepared by two different routes: (1) the intermolecular condensation of the same arylacetonitriles (2) the condensation of arylaldehydes and arylacetonitriles with a catalytic amount of NaOCH3 at room temperature. Several a,b-diarylacrylonitrile derivatives have been synthesised in this paper and characterised. The UV-vis absorption and photoluminescent (PL) spectra of the products were investigated.