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376348-74-2

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376348-74-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 376348-74-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,6,3,4 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 376348-74:
(8*3)+(7*7)+(6*6)+(5*3)+(4*4)+(3*8)+(2*7)+(1*4)=182
182 % 10 = 2
So 376348-74-2 is a valid CAS Registry Number.

376348-74-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-(1-(3-fluorophenyl)-3-oxopropyl)-carbamic acid tert-butyl ester

1.2 Other means of identification

Product number -
Other names [(S)-1-(3-fluorophenyl)-3-oxopropyl]carbamic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:376348-74-2 SDS

376348-74-2Relevant articles and documents

Practical asymmetric synthesis of RO5114436, a CCR5 receptor antagonist

Huang, Xiaojun,O'Brien, Erin,Thai, Felicia,Cooper, Gary

, p. 592 - 599 (2011/07/08)

A practical asymmetric synthesis of a 3,7-diazabicyclo[3.3.0]octane derivative (1), a representative of a new class of potent CCR5 receptor antagonists, is described. The benzylamine stereogenic center of 1 was introduced by a ruthenium-catalyzed asymmetric reductive amination using (R)-MeOBIPHEP as ligand. Aldehyde 4, prepared by Parikh-Doering oxidation, was used without workup in the reductive amination reaction, which not only simplified the process but also overcame the instability of 4. The 3,7-diazabicyclo[3.3.0]octane core was obtained by a [3 + 2] cycloaddition.

IMIDAZOPYRIDINE SUBSTITUTED TROPANE DERIVATIVES WITH CCR5 RECEPTOR ANTAGONIST ACTIVITY FOR THE TREATMENT OF HIV AND INFLAMMATION

-

Page/Page column 42, (2010/02/11)

The present invention provides compounds of formula (I) wherein R1 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.

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