376353-73-0

Upstream product

• 2916-76-9 methyl (trimethylsilyl)acetate 
• 376353-72-9 (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1,4-cyclohexanedione 
• 141404-08-2 (3R,5R)-3,5-bis[tert-butyl(dimethyl)silyloxy]-4-hydroxycyclohexanone 

Downstream Products

• 376353-74-1 [(3'R,5'R)-3',5'-bis[(tert-butyldimethylsilyl)oxy]-4'-ethylidenecyclohexylidene]acetic acid methyl ester 

Relevant academic research and scientific papers

2-Ethyl and 2-ethylidene analogues of 1α,25-dihydroxy-19-norvitamin D3: Synthesis, conformational analysis, biological activities, and docking to the modeled rVDR ligand binding domain

Novel 19-nor analogues of 1α,25-dihydroxyvitamin D3 were prepared and substituted at C-2 with an ethylidene group. The synthetic pathway was via Wittig - Horner coupling of the corresponding A-ring phosphine oxides with the protected 25-hydroxy