376367-55-4Relevant academic research and scientific papers
Metallo-nucleosides: Synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2′-deoxyuridines
Sergeant, Craig D.,Ott, Ingo,Sniady, Adam,Meneni, Srinivasarao,Gust, Ronald,Rheingold, Arnold L.,Dembinski, Roman
, p. 73 - 80 (2008/09/20)
Reactions of 5-alkynyl-2′-deoxyuridines with dicobalt octacarbonyl Co2(CO)8 in THF at room temperature gave hexacarbonyl dicobalt nucleoside complexes (77-93%). The metallo-nucleosides were characterized, including an X-ray structure
5-Alkynyl-2′-deoxyuridines: Chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells
Meneni, Srinivasarao,Ott, Ingo,Sergeant, Craig D.,Sniady, Adam,Gust, Ronald,Dembinski, Roman
, p. 3082 - 3088 (2008/02/01)
Starting with 5-iodo-2′-deoxyuridine, a series of 5-alkynyl-2′-deoxyuridines (with n-propyl, cyclopropyl, 1-hydroxycyclohexyl, p-tolyl, p-tert-butylphenyl, p-pentylphenyl, and trimethylsilyl alkyne substituents) have been synthesized via the palladium-cat
Synthesis of dicobalt hexacarbonyl 5-p-tolylethynyl-2′-deoxyuridine
Esho, Noor,Davies, Brian,Lee, Janet,Dembinski, Roman
, p. 332 - 333 (2007/10/03)
Reactions of 5-p-tolylethynyl-2′-deoxyuridine and 3′,5′-diO-acetyl-5-p-tolylethynyl-2′-deoxyuridine with Co2(CO)8 in THF gave 5-p-tolC2[Co2(CO)6]-2′-deoxyuridine and 3′,5′-diO-acetyl-5-p-tolC2[Co2(CO) 6]-2′-deoxyuridine (92 and 66%).
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain
McGuigan,Barucki,Blewett,Carangio,Erichsen,Andrei,Snoeck,De Clercq,Balzarini
, p. 4993 - 4997 (2007/10/03)
In addition to our recent report on the potent anti-varicella-zoster virus (VZV) activity of some unusual bicyclic furopyrimidine nucleosides bearing long alkyl side chains, we herein report the further significant enhancement of the antiviral potency by
