319425-62-2Relevant academic research and scientific papers
Anti-viral pyrimidine nucleoside analogues
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Page/Page column 8-9; 12, (2016/06/28)
A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; R8 and R9 can be hydrogen, alkyl, cycloalkyl, halogen, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alk
Zinc-catalyzed cycloisomerizations. Synthesis of substituted furans and furopyrimidine nucleosides
Sniady, Adam,Durham, Audrey,Morreale, Marco S.,Marcinek, Andrzej,Szafert, Slawomir,Lis, Tadeusz,Brzezinska, Krystyna R.,Iwasaki, Takanori,Ohshima, Takashi,Mashima, Kazushi,Dembinski, Roman
, p. 5881 - 5889 (2008/12/21)
(Chemical Equation Presented) 5-Endo-dig cycloisomerization of 1,4- and 1,2,4- mostly aryl-substituted but-3-yn-1-ones in the presence of a catalytic amount of zinc chloride etherate (10 mol %) in dichloromethane at room temperature gave 2,5-di- and 2,3,5
NMR conformational analysis of p-tolyl furanopyrimidine 2′-deoxyribonucleoside and crystal structure of its 3′,5′-di- O-acetyl derivative
Esho, Noor,Desaulniers, Jean-Paul,Davies, Brian,Chui, Helen M.-P.,Rao, Meneni Srinivasa,Chow, Christine S.,Szafert, Slawomir,Dembinski, Roman
, p. 1231 - 1238 (2007/10/03)
The conformation of a representative molecule of a new, potent class of antiviral-active modified nucleosides is determined. A bicyclic nucleoside, 3-(2′-deoxy-β-d-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro[2, 3-d]pyrimidin-2-one, shows C2′-endo and C3′-endo ribose conformations in solution (63:37, 37°C; DMSO-d6), as determined by 1H NMR studies. The crystal structure of a 3′,5′-di-O- acetyl-protected derivative (monoclinic, P21, a/b/c = 6.666(1)/12.225(1)/24.676(2) A, β = 90.24(1)°, Z = 4) shows exclusively C2′-endo deoxyribose puckering. The base is found in the anti position both in solution and in crystalline form.
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain
McGuigan,Barucki,Blewett,Carangio,Erichsen,Andrei,Snoeck,De Clercq,Balzarini
, p. 4993 - 4997 (2007/10/03)
In addition to our recent report on the potent anti-varicella-zoster virus (VZV) activity of some unusual bicyclic furopyrimidine nucleosides bearing long alkyl side chains, we herein report the further significant enhancement of the antiviral potency by
