376583-99-2

Upstream product

• 170284-66-9 1-methyl-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-carboxylic acid tert-butyl ester 
• 5946-42-9 methyl 2-(N-bromoacetyl-N-methylamino)benzoate 
• 1133-42-2 1-methyl-1,2,3,4-tetrahydro-3H-1,4-benzodiazepin-2,5-dione 
• 85-91-6 Methyl N-methylanthranilate 
• 376583-98-1 4-(3-benzyloxycarbonylamino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzoic acid 
• 376583-97-0 {5-[4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl}-carbamic acid benzyl ester 
• 412317-51-2 5-[4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-5-hydroxy-1-methyl-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-carboxylic acid tert-butyl ester 
• 376583-96-9 3-amino-5-[4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 376583-94-7 5-[4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 

Downstream Products

• 376584-00-8 4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide 

Relevant academic research and scientific papers

Benzodiazepine derivatives as inhibitors of gamma secretase

Compounds of formula (I) are disclosed. The compounds inhibit the action of gamma secretase, and hence find use in the treatment and prevention of Alzheimer's disease.

A new series of potent benzodiazepine gamma-secretase inhibitors.

A new series of benzodiazepine-containing gamma-secretase inhibitors with potential use in the treatment of Alzheimer's disease is disclosed. Structure-activity relationships of the pendant hydrocinnamate side-chain which led to the preparation of highly