376608-67-2

Usage

Uses

Used in Chemical Industry:
(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate is used as a component in the formulation of adhesives, coatings, and sealants due to its acrylate family membership and versatile reactivity.
Used in Material Sciences:
(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate is used as a building block for the development of new materials, leveraging its potential reactivity and the specific interactions it may have with fluorine-containing molecules.
Used in Pharmaceutical Industry:
(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate may be used as a starting material or intermediate in the synthesis of pharmaceutical compounds, taking advantage of its unique molecular structure and potential for specific molecular interactions.
Used in Research and Development:
(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate serves as a subject of study in research and development, where its properties and reactivity are explored for potential applications in various scientific and industrial fields.

Upstream product

• 112897-97-9 (E)-3-(3,4-difluorophenyl)acrylic acid 
• 376608-66-1 (E)-3-(3,4-difluorophenyl)acryloyl chloride 
• 2216-51-5 (-)-menthol 
• 34036-07-2 3,4 difluorobenzaldehyde 

Downstream Products

• 376608-68-3 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylate 

Relevant academic research and scientific papers

Environment-friendly preparation method of ticagrelor intermediate

The invention discloses an environment-friendly preparation method of a ticagrelor intermediate. According to the method, (E)-3-(3,4-difluorophenyl)menthyl acrylate with chiral menthol groups is obtained by subjecting 3,4-difluorobenzaldehyde used as a ra

Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover

A benchtop stable, bifunctional reagent for the redox-neutral cyclopropanation of olefins has been developed. Triethylammonium bis(catecholato)iodomethylsilicate can be readily prepared on multigram scale. Using this reagent in combination with an organic photocatalyst and visible light, cyclopropanation of an array of olefins, including trifluoromethyl- and pinacolatoboryl-substituted alkenes, can be accomplished in a matter of hours. The reaction is highly tolerant of traditionally reactive functional groups (carboxylic acids, basic heterocycles, alkyl halides, etc.) and permits the chemoselective cyclopropanation of polyolefinated compounds. Mechanistic interrogation revealed that the reaction proceeds via a rapid anionic 3-exo-tet ring closure, a pathway consistent with experimental and computational data.

Process for the preparation of cyclopropyl carboxylic acid esters and derivatives

The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.