37670-55-6Relevant academic research and scientific papers
Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides
Nadres, Enrico T.,Lazareva, Anna,Daugulis, Olafs
experimental part, p. 471 - 483 (2011/04/15)
The palladium-catalyzed direct arylation of indoles, pyrroles, and furans by aryl chlorides has been demonstrated. The method employs a palladium acetate catalyst, 2-(dicyclohexylphosphino)-biphenyl ligand, and an inorganic base. Electron-rich and electron-poor aryl chlorides as well as chloropyridine coupling partners can be used, and arylated heterocycles are obtained in moderate to good yields. Optimization of base, ligand, and solvent is required for achieving best results.
The application of vinylogous iminium salts and related synthons to the regiocontrolled preparation of 2,3- and 2,5-disubstituted pyrroles
Gupton, John T.,Petrich, Scott A.,Smith, Lana L.,Bruce, Marc A.,Vu, Phong,Du, Karen X.,Dueno, Eric E.,Jones, Claude R.,Sikorski, James A.
, p. 6879 - 6892 (2007/10/03)
The reaction of 1-substituted vinamidinium salts with sarcosine ethyl ester produced 2,3-disubstituted pyrroles; a similar reaction with glycine ethyl ester gave 2,5-disubstituted pyrroles. Reactions of related three-carbon synthons with sarcosine and gly
An Efficient, Regiocontrolled Synthesis of 5-Aryl-2-carbethoxypyrroles from 3-Aryl-3-chloropropeniminium Salts
Gupton, John T.,Krolikowski, Dale A.,Yu, Richard H.,Vu, Phong,Sirkorski, James A.,et al.
, p. 5480 - 5483 (2007/10/02)
A variety of 3-aryl-3-chloropropeniminium salts react with α-amino acid esters under basic conditions to produce 2-carbethoxy-5-arylpyrroles in a regioselective manner.The overall process represents a short, efficient, and convergent synthesis of 2,5-disu
