377078-83-6

Basic information

• Product Name: (2R,3S)-3-(2,2-diethoxyethyl)amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
• Synonyms: (2R,3S)-3-(2,2-diethoxyethyl)amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
• CAS NO: 377078-83-6
• Molecular Weight: 384.426
• Mol File: 377078-83-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-(2,2-diethoxyethyl)amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-(2,2-diethoxyethyl)amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol(377078-83-6)
• EPA Substance Registry System: (2R,3S)-3-(2,2-diethoxyethyl)amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol(377078-83-6)

Safety Data

• Hazardous Substances Data: 377078-83-6(Hazardous Substances Data)

Upstream product

• 138511-90-7 [(1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] methanesulfonate 
• 126918-33-0 (1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 135270-13-2 1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 
• 645-36-3 2,2-diethoxy-ethanamine 

Downstream Products

• 377078-89-2 1-[(1S,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-(1H,3H)-imidazolone 
• 377078-86-9 1-(2,2-diethoxyethyl)-1-[(1S,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea 

Relevant articles and documents

Optically active antifungal azoles. XIII. Synthesis of stereoisomers and metabolites of 1-[(1Rr,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3(1H-1,2,4-triazol-1- yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456)

1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1- yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyll-2-imidazolidinone [(1R,2R)-1: TAK-456] is a new antifungal agent selected as a candidate for clinical trials. The three stereoisomers [(1S