1H-Benzimidazole-2-carboxaldehyde,1,5-dimethyl-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole-2-carboxaldehyde,1,5-dimethyl-(9CI)
• CAS No.: 37735-10-7
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.202
• Mol file: 37735-10-7.mol

Synonyms:1,5-Dimethyl-2-benzimidazolecarboxaldehyde;2-Benzimidazolecarboxaldehyde, 1,5-dimethyl-

Chemical Property of 1H-Benzimidazole-2-carboxaldehyde,1,5-dimethyl-(9CI)

Chemical Property:

• PSA: 34.89000
• LogP: 1.69420

Purity/Quality:

97% ^*data from raw suppliers

1,5-Dimethyl-1H-benzo[d]imidazole-2-carbaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-2-carboxaldehyde,1,5-dimethyl-(9CI)

There total 6 articles about 1H-Benzimidazole-2-carboxaldehyde,1,5-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(N-methyl-5-methyl-1H-benzimidazole-2-yl)methanol (68426-72-2) → 1,5-dimethyl-1H-benzoimidazole-2-carbaldehyde (37735-10-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 6h;

DOI:10.5012/bkcs.2013.34.4.1272

Reference yield:

(5-methyl-1H-benzimidazole-2-yl)methanol (20034-02-0) + methyl iodide (74-88-4) → C10H10N2O + 1,5-dimethyl-1H-benzoimidazole-2-carbaldehyde (37735-10-7)

Guidance literature:

(5-methyl-1H-benzimidazole-2-yl)methanol; methyl iodide; With potassium carbonate; In N,N-dimethyl-formamide;

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2016.07.019

Reference yield:

4-methyl-1,2-diaminobenzene (496-72-0) → C10H10N2O + 1,5-dimethyl-1H-benzoimidazole-2-carbaldehyde (37735-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide

2.2: 0 - 20 °C

With hydrogenchloride; potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2016.07.019

upstream raw materials:

(5-methyl-1H-benzimidazole-2-yl)methanol

4-methyl-1,2-diaminobenzene

(N-methyl-5-methyl-1H-benzimidazole-2-yl)methanol

methyl iodide

Downstream raw materials:

C₂₁H₂₀N₂O₃