37759-73-2

Usage

Uses

Used in Organic Synthesis:
(E)-4,4-difluoro-but-2-enoic acid is used as a building block for the synthesis of various pharmaceutical compounds, leveraging its unique chemical properties to create a wide range of molecules with potential applications in the medical field.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (E)-4,4-difluoro-but-2-enoic acid serves as a reagent in organic chemical reactions, contributing to the development of new drugs and therapeutic agents. Its fluorinated nature and reactivity make it a promising candidate for the creation of novel pharmaceuticals with improved properties, such as enhanced bioavailability and targeted action.
Overall, (E)-4,4-difluoro-but-2-enoic acid is a versatile compound with significant applications in the fields of organic chemistry and pharmaceutical research, playing a crucial role in the synthesis of new molecules and the advancement of drug development.

Upstream product

• 430-69-3 2,2-difluoroacetaldehyde 
• 141-82-2 malonic acid 
• 37746-82-0 ethyl (E)-4,4-difluoro-but-2-enoate 

Downstream Products

• 1609467-19-7 5-amino-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]piperidin-3-yl}-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide 
• 1609467-38-0 5-amino-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]piperidin-3-yl}-3-(4-{[6-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1H-pyrazole-4-carboxamide 
• 1609467-30-2 5-amino-3-{4-[(5-chloro-3-fluoropyridin-2-yl)oxy]phenyl}-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]piperidin-3-yl}-1H-pyrazole-4-carboxamide 
• 1609467-08-4 5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]piperidin-3-yl}-1H-pyrazole-4-carboxamide 
• 37746-82-0 ethyl (E)-4,4-difluoro-but-2-enoate 

Relevant academic research and scientific papers

Fluoroalkyl-substituted cyclopropane derivatives: Synthesis and physicochemical properties

A series of all 12 cis- and trans-cyclopropanecarboxylic acids and cyclopropylamines bearing CH2F, CHF2, and CF3 substituents were synthesized by different methods on a multigram scale. Dissociation constants (pKa) and log P values were measured for the o

SUMO INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds and compositions capable of acting as inhibitors of small ubiquitin-like modifier (SUMO) family of proteins. The compounds and compositions may be used in the treatment of cancer. There are disclosed, inter alia, methods of inhibiting an E1 enzyme, and compounds useful for inhibiting an E1 enzyme.

IMPROVED PROCESS FOR PREPARING SUBSTITUTED CROTONIC ACIDS

A process to prepare a compound of Formula (I) wherein R3, R4 and R5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

BRUTON'S TYROSINE KINASE INHIBITORS

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)